Abstract
A pseudo four-component reaction is described, leading to the efficient regioselective synthesis of σ symmetric spiro heterobicyclic rings using aldehydes and urea in the presence of cyclic β-diester or β-diamides such as Meldrum's acid or barbituric acid derivatives. The reaction needs no added catalyst and proceeds solvent-free conditions at 80 °C.
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Shaabani, A., Bazgir, A. & Bijanzadeh, H.R. A reexamination of Biginelli-like multicomponent condensation reaction: One-pot regioselective synthesis of spiro heterobicyclic rings. Mol Divers 8, 141–145 (2004). https://doi.org/10.1023/B:MODI.0000025613.35304.25
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DOI: https://doi.org/10.1023/B:MODI.0000025613.35304.25