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Getting more from IR-microscopy of resin-bound libraries

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Abstract

A linear pixel-array detector was employed to create spatially resolved multi-layered IR-images of a large collection of polymer beads supporting carbonyl and nitrile monomers. The feasibility of creating multi-layered IR-images with nitrile IR-band separation of 4 cm-1 was demonstrated, an important issue when considering that many monomers used to develop combinatorial libraries are structurally analogous and therefore occupy very similar positions in the IR-spectrum. Strategies for obtaining high quality spectral data from both imaging and mapping IR-microscopes without compromising on sample area, analysis time, or spatial resolution are also described.

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Authors and Affiliations

  1. Combinatorial Centre of Excellence, Department of Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, United Kingdom

    Gurjit S. Mandair, Andrea E. Russell & Mark Bradley

  2. PerkinElmer Instruments, Chalfont Road, Seer Green, Bucks, HP9 2FX, United Kingdom

    Gavin Aston

Authors
  1. Gurjit S. Mandair
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  2. Andrea E. Russell
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  3. Gavin Aston
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  4. Mark Bradley
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Correspondence to Andrea E. Russell.

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Mandair, G.S., Russell, A.E., Aston, G. et al. Getting more from IR-microscopy of resin-bound libraries. Mol Divers 8, 135–139 (2004). https://doi.org/10.1023/B:MODI.0000025608.57381.10

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  • DOI: https://doi.org/10.1023/B:MODI.0000025608.57381.10

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