Abstract
By fulfilling the specific design criteria required for safe andreproducible microwave synthesis, Personal Chemistry introducedthe first microwave system designed for organic chemistry in2000.
The principle of microwave synthesis offers 3 major benefits tochemistry development: speed, reproducibility, and a scalableapproach to compound synthesis. Additionally, significantadvantages of our technical solution are ease of use, safety,verified synthesis methods to enable new users, and an efficientworkflow that fits the drug discovery process.
To gain the greatest advantages offered by microwave synthesis,Personal Chemistry has implemented a system called CoherentSynthesis. Incorporating planning systems, automation,distributed system access, searchable databases and reactionoptimisation kits, the technology has already proved itself todramatically improve the quality of output from medicinalchemistry for lead optimisation in all the major pharmaceuticaland biotech companies.
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References and Notes
Wilson, N. S. and Roth, G. P., Recent trends in microwaveassisted synthesis, Curr. Opinion Drug Discov. Develop., 5(4) (2002) 620–629.
Stadler, A. and Kappe, C. O., Automated library generation using sequential microwave-assisted chemistry. Application toward the Biginelli multicomponent condensation, J. Combinat. Chem., 3 (2001) 624–630.
Wilson, N. S., Sarko, C. R. and Roth, G. P., Microwaveassisted synthesis of a [3+2] cycloaddition library, Tetrahedron Lett., 42 (2001), 8939–8941.
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Schanche, JS. Microwave synthesis solutions from personal chemistry. Mol Divers 7, 291–298 (2003). https://doi.org/10.1023/B:MODI.0000006866.38392.f7
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DOI: https://doi.org/10.1023/B:MODI.0000006866.38392.f7