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New MCRs: The first 4-component reaction leading to 2,4-disubstituted thiazoles

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Abstract

New organic reactions allow chemical transformations which were previously not possible. Therefore, new reactions are important contributions to the progress in the field of organic synthesis.In this series we describe the design, scope, and limitations of newly-discovered multi-component reactions (MCRs). Herein, a first example of a MCR is introduced which allows general access to the class of 2,4-di- and 2,4,5-trisubstituted thiazoles.

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Authors and Affiliations

  1. Institut für Organische Chemie und Biochemie, Technische Universität München, Garching, Germany

    Jürgen Kolb

  2. Morphochem AG, München, Germany

    Barbara Beck, Michael Almstetter, Stefan Heck & Alexander Dömling

  3. Institut für Anorganische Chemie, Technische Universität München, Garching, Germany

    Eberhardt Herdtweck

  4. Institut für Organische Chemie und Biochemie, Technische Universität München, Garching, Germany

    Alexander Dömling

Authors
  1. Jürgen Kolb
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  2. Barbara Beck
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  3. Michael Almstetter
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  4. Stefan Heck
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  5. Eberhardt Herdtweck
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  6. Alexander Dömling
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Correspondence to Alexander Dömling.

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Kolb, J., Beck, B., Almstetter, M. et al. New MCRs: The first 4-component reaction leading to 2,4-disubstituted thiazoles. Mol Divers 6, 297–313 (2003). https://doi.org/10.1023/B:MODI.0000006827.35029.e4

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