Abstract
In this study, the microwave-assisted Pd(0)-catalyzed coupling of aryl halides to Rink resins is compared to a conventional heating protocol. While yields and purities of the coupling products were comparable under both conditions, microwave heating allows a significant acceleration of the reaction. The coupling of electron-deficient aryl halides proceeded within 10–15 minutes, while under conventional conditions 20 h of heating were necessary for complete conversion.
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Weigand, K., Pelka, S. Microwave-assisted Pd(0)-catalyzed amination of aryl halides on solid support. Mol Divers 7, 181–184 (2003). https://doi.org/10.1023/B:MODI.0000006821.42063.6b
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DOI: https://doi.org/10.1023/B:MODI.0000006821.42063.6b