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A rapid microwave protocol for Heck vinylation of aryl chlorides under air

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Abstract

In modern high-throughput chemistry, the overall workflow is a crucial factor and much work is devoted to speeding up the process of chemistry development. Since automated microwave-based synthesizers are known to streamline the compound production and to accelerate slow organic transformations, this technology was implemented for Heck reactions with sluggish aryl chlorides. Furthermore, homogeneous palladium-catalyzed Heck vinylations of aryl chlorides can be performed under air under optimized conditions. Based on this finding, controlled microwave heating was utilized to accelerate model reactions down to 30 min employing a mixture of ionic liquid and 1,4-dioxane as solvent.

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Authors and Affiliations

  1. Department of Organic Pharmaceutical Chemistry, Biomedical Centre, Uppsala University, Uppsala, Sweden

    Gopal K. Datta, Karl S. A. Vallin & Mats Larhed

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  1. Gopal K. Datta
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  2. Karl S. A. Vallin
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  3. Mats Larhed
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Correspondence to Mats Larhed.

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Datta, G.K., Vallin, K.S.A. & Larhed, M. A rapid microwave protocol for Heck vinylation of aryl chlorides under air. Mol Divers 7, 107–114 (2003). https://doi.org/10.1023/B:MODI.0000006798.53091.a2

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  • DOI: https://doi.org/10.1023/B:MODI.0000006798.53091.a2

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