A novel four-component reaction approach to the efficient synthesis of triamide and amidodiester derivatives using amines or alcohols, aldehydes and alkyl or aryl isocyanides in the presence of Meldrum's acid as a CH acid, instead of carboxylic acid of Ugi four-component reaction, was studied.
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Shaabani, A., Teimouri, M.B., Bazgir, A. et al. Introducing a novel class of four-component reactions. Mol Divers 6, 199–206 (2003). https://doi.org/10.1023/B:MODI.0000006759.20910.f1
- Meldrum's acid