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Introducing a novel class of four-component reactions


A novel four-component reaction approach to the efficient synthesis of triamide and amidodiester derivatives using amines or alcohols, aldehydes and alkyl or aryl isocyanides in the presence of Meldrum's acid as a CH acid, instead of carboxylic acid of Ugi four-component reaction, was studied.

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Correspondence to Ahmad Shaabani.

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Shaabani, A., Teimouri, M.B., Bazgir, A. et al. Introducing a novel class of four-component reactions. Mol Divers 6, 199–206 (2003).

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  • alcohol
  • amidodiester
  • amine
  • isocyanide
  • Meldrum's acid
  • triamide