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Nitric oxide and promotion of cardiac myocyte apoptosis

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Abstract

The removal of damaged, superfluous or energy-starved cells is essential for biological homeostasis, and occurs in every tissue type. Programmed cell death occurs through several closely regulated signal pathways, including apoptosis, in which cell components are broken down and packaged into small membrane-bound fragments that are then removed by neighbouring cells or phagocytes. This process is activated in the cardiac myocyte in response to a variety of stresses, including oxidative and nitrosative stress, and involves mitochondria-derived signals. Loss of cardiac myocytes through apoptosis has been shown to induce cardiomyopathy in a variety of gene-targeted animal models. Because cardiac myocytes have strictly limited ability to regenerate, sustained programmed cell death is likely to contribute to the development and progression of heart failure in a variety of myocardial diseases. At the same time, the cardiac myocyte possesses a number of mechanisms for defence against short-term haemodynamic and oxidative stresses. Our laboratory has recently examined the role of nitric oxide (NO) as a regulator of the programmed death of cardiac myocytes, and the potential contribution of NO and NO-dependent signalling to the loss of myocytes in heart failure. We will review the role of c-Jun N-terminal kinase in response to oxidative and nitrosative stress, and summarise evidence for its role as a cytoprotective mechanism. We will also review evidence implicating NO in the pathophysiology of heart failure, in the context of the extensive and sometimes contradictory body of research on NO and cell survival. (Mol Cell Biochem 263: 35–53, 2004)

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  1. Semmelweis University Faculty of Medicine, Department of Medicine, Budapest, Hungary and, University of Miami School of Medicine, FL, USA

    Péter Andréka

  2. Department of Molecular and Cellular Pharmacology, Miami, FL, USA

    Thanh Tran, Keith A. Webster & Nanette H. Bishopric

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Andréka, P., Tran, T., Webster, K.A. et al. Nitric oxide and promotion of cardiac myocyte apoptosis. Mol Cell Biochem 263, 35–53 (2004). https://doi.org/10.1023/B:MCBI.0000041847.63338.b8

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