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p53 Expression in circulating lymphocytes of non-melanoma skin cancer patients from an arsenic contaminated region in Mexico. A pilot study

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Abstract

Arsenic is a common environmental toxicant and epidemiological studies associate arsenic exposure with various pathologic disorders and several types of cancer. Skin cancers are the most common arsenic-induced neoplasias and the prevalence of skin lesions has been reported to be significantly elevated in individuals exposed to arsenic via drinking water in México. Being lymphocytes the main cells used for human monitoring, we evaluated the expression of p53 protein in the lymphocytes from 44 healthy individuals and 19 samples from individuals living in a chronic arsenicism endemic region. Of the latter group, 12 individuals had non-melanoma skin cancer and 9 of them expressed p53 in the circulating lymphocytes, whereas only one of the 7 non-cancer arsenic exposed individuals expressed it. In the healthy non-arsenic exposed group only one from 44 individuals expressed the protein. These results suggest a clear relationship between non-melanoma skin cancer and p53 expression in circulating lymphocytes. p53 expression in circulating lymphocytes should be evaluated as a potential biomarker of effect or susceptibility.

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Authors and Affiliations

  1. Instituto de Investigaciones Biomédicas, UNAM, Mexico

    Ana M. Salazar, Monserrat Sordo, Andrés Bendesky & Patricia Ostrosky-Wegman

  2. Centro de Investigación y Estudios Avanzados, IPN, México

    Emma Calderón-Aranda, Mariano E. Cebrián, Arístides Gómez-Muñoz & Leonor Acosta-Saavedra

  3. Facultad de Medicina, UNAM, Mexico

    Andrés Bendesky

Authors
  1. Ana M. Salazar
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  2. Emma Calderón-Aranda
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  3. Mariano E. Cebrián
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  4. Monserrat Sordo
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  5. Andrés Bendesky
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  7. Leonor Acosta-Saavedra
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  8. Patricia Ostrosky-Wegman
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Salazar, A.M., Calderón-Aranda, E., Cebrián, M.E. et al. p53 Expression in circulating lymphocytes of non-melanoma skin cancer patients from an arsenic contaminated region in Mexico. A pilot study. Mol Cell Biochem 255, 25–31 (2004). https://doi.org/10.1023/B:MCBI.0000007258.33942.f8

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  • DOI: https://doi.org/10.1023/B:MCBI.0000007258.33942.f8

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