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Journal of Structural and Functional Genomics

, Volume 4, Issue 4, pp 245–255 | Cite as

Computational approaches to protein-protein interaction

  • Giacomo Franzot
  • Oliviero Carugo
Article

Abstract

The interactions between proteins allow the cell's life. A number of experimental, genome-wide, high-throughput studies have been devoted to the determination of protein-protein interactions and the consequent interaction networks. Here, the bioinformatics methods dealing with protein-protein interactions and interaction network are overviewed. 1. Interaction databases developed to collect and annotate this immense amount of data; 2. Automated data mining techniques developed to extract information about interactions from the published literature; 3. Computational methods to assess the experimental results developed as a consequence of the finding that the results of high-throughput methods are rather inaccurate; 4. Exploitation of the information provided by protein interaction networks in order to predict functional features of the proteins; and 5. Prediction of protein-protein interactions.

Functional genomics protein function prediction protein interaction databases protein interaction networks proteinrotein interaction proteomics 

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Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • Giacomo Franzot
    • 1
    • 2
  • Oliviero Carugo
    • 3
    • 4
    • 5
  1. 1.International School for Advanced StudiesTriesteItaly
  2. 2.Sincrotrone Trieste, Strada StataleBasovizza, TriesteItaly
  3. 3.Department of General ChemistryPavia UniversityPaviaItaly
  4. 4.International Centre for Genetic Engineering and BiotechnologyTriesteItaly
  5. 5.Laboratorio Nazionale TASCIstituto Nazionale per la Fisica della MateriaTriesteItaly

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