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Labeling of famotidine with 99mTc and biodistribution studies on rats

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Abstract

Famotidine, a gastrointestinal drug was labeled with 99mTc and its radiopharmaceutical potential was observed on male Albino Wistar rats. Labeling yield was over 95%. Average specific activity and n-octanol/water partition coefficient (lipophilicity) were approximately 74 MBq/mg-0.66 GBq/mg and 3.4, respectively. Biodistribution studies were performed on Albino Wistar rats. The activity per gram tissue was calculated and time-activity curves were generated. The majority of the activity was observed in stomach, small intestines and kidneys. Liver and kidneys showed lower uptake compared to other H2-receptor rich tissues. Results show that 99mTc-famotidine is H2receptor specific.

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Authors and Affiliations

  1. Institute of Nuclear Sciences, Department of Nuclear Applications Bornova, Ege University, Izmir, 35100, Turkey

    P. Unak, F. Y. Lambrecht, F. Z. Biber, İ. E. Medine & S. Teksoz

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  1. P. Unak
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  2. F. Y. Lambrecht
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  3. F. Z. Biber
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  4. İ. E. Medine
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  5. S. Teksoz
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Unak, P., Lambrecht, F.Y., Biber, F.Z. et al. Labeling of famotidine with 99mTc and biodistribution studies on rats. Journal of Radioanalytical and Nuclear Chemistry 261, 587–591 (2004). https://doi.org/10.1023/B:JRNC.0000037099.75789.29

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  • DOI: https://doi.org/10.1023/B:JRNC.0000037099.75789.29

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