Abstract
In order to visualize hypoxic tissues, a 99mTc complex containing a nitroimidazole group was evaluated. A new dithiocarbamate ligand, potassium 2-(4-nitro-1H-imidazolyl)ethyl dithiocarbamate (NIET) was synthesized. The corresponding nitridotechnetium complex was formed by a ligand exchange method. The dependence of the radiolabeling yield of 99mTcN-NIET on the amount of added stannous chloride and other parameters was screened by the normal procedure. Under optimized labeling conditions, the radiolabeling yield of 99mTcN-NIET is about 90%. The biodistribution of 99mTcN-NIET in mice bearing S180 tumor demonstrated some uptake in tumor and a tumor-to-muscle ratio of 3.14 at 4 hours after injection.
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Chu, T., Li, R., Hu, S. et al. Synthesis and biodistribution of the 99mTc nitrido complex with 2-(4-nitro-1H-imidazolyl)ethyl dithiocarbamate (NIET). Journal of Radioanalytical and Nuclear Chemistry 261, 199–202 (2004). https://doi.org/10.1023/B:JRNC.0000030957.77606.00
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DOI: https://doi.org/10.1023/B:JRNC.0000030957.77606.00