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Radioisotopic tracing of lanthanide uptake in erythrocyte, using ytterbium (169Yb3+) and mouse erythrocytes

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Abstract

This study describes a highly sensitive and simple method of 169Yb tracing to investigate the uptake of Yb3+ in mouse erythrocyte. The amounts of Yb3+ absorbed by erythrocyte, membrane and cytoplasm at different time were determined after erythrocytes were incubated with 1.0.10-6mol.l-1 169Yb3+ solution at 37°C. The results indicated that Yb3+ absorbed on the membrane was transferred promptly to the cytoplasm during the separation process. The observation of a very low level of Yb3+ in the cytoplasm could not lead to a verdict that Yb3+ could travel across the erythrocyte membrane

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Authors and Affiliations

  1. Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, P.R. China

    Q. Y. Xie, H. F. Wang & Z. Q. Ji

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  1. Q. Y. Xie
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  2. H. F. Wang
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  3. Z. Q. Ji
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Xie, Q.Y., Wang, H.F. & Ji, Z.Q. Radioisotopic tracing of lanthanide uptake in erythrocyte, using ytterbium (169Yb3+) and mouse erythrocytes. Journal of Radioanalytical and Nuclear Chemistry 261, 145–149 (2004). https://doi.org/10.1023/B:JRNC.0000030948.91822.da

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  • DOI: https://doi.org/10.1023/B:JRNC.0000030948.91822.da

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