Abstract
A method based on flow injection extraction chromatography coupled to on-line ICP-MS (FI-EXC-ICPMS) has been developed and validated for simultaneous thorium and uranium determination in human body fluids. By using extraction chromatography, the limits of detection achieved for 232Th, 235U and 238U were 0.06 ng.l-1, 0.0014 ng.l-1 and 0.05 ng.l-1, respectively. The accuracy of the FI-EXC-ICPMS method was 102.4% and 101.5% with overall precision (RSDmax at 95% CI) of 5.3% and 4.9% for 232Th and 238U, respectively. The 235U/238U atom ratio is measured with 1.8% precision. The technique was employed for simultaneous thorium and uranium analyses in human urine and blood samples after microwave digestion.
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References
Unscear, Sources and Effects of Ionization Radiation. Report to the General Assembly with Scientific Annex, Vol. 1, United Nations, New York, 2000.
M. Lederer, V. S. Shirley (Eds), Table of Isotopes, Wiley & Sons, New York, 1978.
H. Taylor (Ed.), Inductively Coupled Plasma Mass Spectroscopy: Practices and Techniques, Academic Press, New York, 2001.
E. P. Horwitz, R. Chiarizia, M. L. Dietz, H. Diamond, D. M. Nelson, Anal. Chim. Acta, 281 (1993) 361.
E. P. Horwitz, M. L. Dietz, R. Chiarizia, H. Diamond, A. M. Essling, D. Graczyk, Anal. Chim. Acta, 266 (1992) 25.
A. H. Thakkar, J. Radioanal. Nucl. Chem., 252 (2002) 215.
J. Kuwabara, S. Tolmachyov, H. Noguchi, J. Nucl. Sci. Technol., Suppl., 3 (2002) 556.
L. Perna, M. Betti, J. M. Barrero Moreno, R. Fuoco, J. Anal. At. Spectrom., 16 (2001) 26.
J. B. Truscott, P. Jones, B. E. Fairman, E. H. Evans, Anal. Chim. Acta, 433 (2001) 245.
C. M. Riley, T. W. Rosanske (Eds), Development and Validation of Analytical Methods, Pergamon Press, Oxford, 1996.
B. G. Ting, D. C. Paschal, J. M. Jarrett, J. L. Pirkle, R. J. Jackson, E. J. Sampson, D. T. Miller, S. P. Caudill, Environ. Res., A81 (1999) 45.
A. Lorber, Z. Karpas, L. Halicz, Anal. Chim. Acta, 334 (1996) 295.
H. S. Dang, D. D. Jaiswal, V. R. Pullat, U. C. Mishra, J. Radioanal. Nucl. Chem., 243 (2000) 513.
H. S. Dang, V. R. Pullat, Health Phys., 65 (1993) 303.
S. S. Shapiro, M. B. Wilk, Biometrika, 52 (1965) 591.
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Tolmachyov, S.Y., Kuwabara, J. & Noguchi, H. Flow injection extraction chromatography with ICP-MS for thorium and uranium determination in human body fluids. Journal of Radioanalytical and Nuclear Chemistry 261, 125–131 (2004). https://doi.org/10.1023/B:JRNC.0000030945.53499.1c
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DOI: https://doi.org/10.1023/B:JRNC.0000030945.53499.1c