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Anti-Apoptotic Effect of Nerve Growth Factor Is Lost in Congenital Insensitivity to Pain with Anhidrosis (CIPA) B Lymphocytes

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Abstract

Congenital insensitivity to pain with anhidrosis (CIPA) is identified as a genetic disorder of mutations in the human TrkA known as high affinity receptor of nerve growth factor (NGF). NGF signal through TrkA promotes anti-apoptotic activity in hematopoietic cells including B lymphocytes. Here we studied the effect of NGF on anti-apoptotic activity by using human EBV-immortalized B lymphoblastoid cell lines (EB-LCLs) derived from a patient with CIPA and the associated carriers of CIPA. The TrkA(mt/mt) EB-LCL derived from the CIPA patient and the TrkA(wt/mt) EB-LCL derived from the carrier with the heterozygous TrkA mutation did not show any responses to NGF on anti-apoptotic activity. We concluded that this phenomenon is one of the pathogeneses of CIPA.

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Authors and Affiliations

  1. Department of Pediatrics, Dokkyo University School of Medicine, Mibu, Tochigi, Japan

    Yuya Sato, Yayoi Tsuboi, Hidemitsu Kurosawa, Kenichi Sugita & Mitsuoki Eguchi

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  1. Yuya Sato
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  2. Yayoi Tsuboi
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  3. Hidemitsu Kurosawa
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  4. Kenichi Sugita
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  5. Mitsuoki Eguchi
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Sato, Y., Tsuboi, Y., Kurosawa, H. et al. Anti-Apoptotic Effect of Nerve Growth Factor Is Lost in Congenital Insensitivity to Pain with Anhidrosis (CIPA) B Lymphocytes. J Clin Immunol 24, 302–308 (2004). https://doi.org/10.1023/B:JOCI.0000025452.79585.a1

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  • DOI: https://doi.org/10.1023/B:JOCI.0000025452.79585.a1

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