Abstract
HIV patients either on highly active antiviral therapy (HAART) or therapy naive were analyzed for their CD56 phenotype and cytokine production in comparison to healthy controls (HC). Both NK cell populations (CD56dim and CD56bright) are found to be present in all groups with selectively decreased CD56dim NK cells in HAART naive patients. Patients on HAART exhibited significantly diminished numbers of CD161+CD56dim NK cells. CD56dim were equally potent in producing IFNγ in all three groups. The number of TNFα+CD56bright NK cells from patients on HAART and TNFα+CD56dim NK cells from HAART naive patients was significantly reduced as compared to healthy controls. In summary our data revealed that functional capacities and coexpression patterns of lectin-like receptors on lymphocytes are differentially affected in HIV patients depending on the state of therapy (under HAART or HAART naive) or the cell type (NK or T cells), respectively.
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Jacobs, R., Weber, K., Wendt, K. et al. Altered Coexpression of Lectin-Like Receptors CD94 and CD161 on NK and T Cells in HIV Patients. J Clin Immunol 24, 281–286 (2004). https://doi.org/10.1023/B:JOCI.0000025449.16468.6f
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DOI: https://doi.org/10.1023/B:JOCI.0000025449.16468.6f