Skip to main content
SpringerLink
Log in

Antibody Response to Influenza Vaccination in Splenectomized Patients in Poland

  • Published:
Journal of Clinical Immunology Aims and scope Submit manuscript

Abstract

The aim of this study was to assess antibody response in 62 splenectomized patients and in 55 healthy subjects vaccinated with split influenza vaccine (“Fluarix,” SmithKline Beecham). Response to hemagglutinin and neuraminidase was assessed before vaccination and after 1 month by hemagglutination inhibition test and neuraminidase inhibition test. After vaccination, antibody titers significantly increased in both groups. Postvaccination protection rates ranged from 62.9 to 90.3% in the splenectomized patients and from 81.8 to 94.5% in the control group. Response rates ranged from 50.0 to 75.8% and from 60.0 to 70.9%, respectively. Splenectomized patients produced high antibody levels regardless of the time elapsed from the operation to the vaccination. All requirements of the Committee for Proprietary Medicinal Products regarding humoral response to influenza vaccination in healthy people were fulfilled in both groups. The response in the splenectomized patients was comparable to that in the control group.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. Brydak LB: Influenza and Its Prophylaxis. Warsaw, Poland, Springer PWN, 1998 (in Polish)

    Google Scholar 

  2. Centers for Disease Control and Prevention (CDC): Severe morbidity and mortality associated with influenza in children and young adults—Michigan, 2003. Morb Mortal Wkly Rep 52(35):837-840, 2003

    Google Scholar 

  3. Neuzil KM, Maynard C, Griffin MR, Heagerty P: Winter respiratory viruses and health care use: A population-based study in the northwest United States. Clin Infect Dis 37(2):201-207, 2003

    Google Scholar 

  4. Goddard NL, Joseph CA, Watson JM, Ellis JS, Zambon MC: Three years of low influenza activity—no reason for complacency. Commun Dis Public Health 6(2):128-132, 2003

    Google Scholar 

  5. Ellis SE, Coffey CS, Mitchel EF Jr, Dittus RS, Griffin MR: Influenza and respiratory syncytial virus-associated morbidity and mortality in the nursing home population. J Am Geriatr Soc 51(6):761-767, 2003

    Google Scholar 

  6. Paget WJ, Meerhoff TJ, Goddard NL, EISS: Mild to moderate influenza activity in Europe and the detection of novel A(H1N2) and B viruses during the winter of 2001–02. Eur Commun Dis Bull (Euro Surveillance: Bulletin Europeen sur les Maladies Transmissibles) 7(11):147-157, 2002

    Google Scholar 

  7. Neuzil KM, Hohlbein C, Zhu YW: Illness among schoolchildren during influenza season—effect on school absenteeism, parental absenteeism from work, and secondary illness in families. Arch Pediatr Adolesc Med 156(10):986-991, 2002

    Google Scholar 

  8. Nichol KL: The efficacy, effectiveness and cost-effectiveness of inactivated influenza virus vaccines. Vaccine 21(16):1769-1775, 2003

    Google Scholar 

  9. Van Essen GA, Palache AM, Forleo E, Fedson DS: Influenza vaccination in 2000: Recommendations and vaccine use in 50 developed and rapidly developing countries. Vaccine 21(16):1780-1785, 2003

    Google Scholar 

  10. Nicholson KG: Socioeconomics of influenza and influenza vaccination in Europe. Pharmacoecon 9(3):75-78, 1996

    Google Scholar 

  11. Ghendon Y: The immune response to influenza vaccines. Acta Virol 34:295-304, 1990

    Google Scholar 

  12. Centers for Disease Control and Prevention: Prevention and control of influenza: Recommendations of the Advisory Committee on Immunization Practices (ACIP). Morb Mortal Wkly Rep 52(RR-8): 2003

  13. Wilde JA, McMillan JA, Serwint J, Butta J, O'Riordan MA, Steinhoff MC: Effectiveness of influenza vaccine in health care professionals: A randomized trial. JAMA 281:908-913, 1999

    Google Scholar 

  14. Demicheli W, Jefferson T, Rivetti D, Deeks J: Prevention and early treatment of influenza in healthy adults. Vaccine 18:957-1030, 2000

    Google Scholar 

  15. Monto AS, Hornbuckle K, Ohmit SE: Influenza vaccine effectiveness among elderly nursing home residents: A cohort study. Am J Epidemiol 154:155-160, 2001

    Google Scholar 

  16. Davidson RN, Wall RA: Prevention and management of infections in patients without a spleen. Clin Microbiol Infect 7(12):657-660, 2001

    Google Scholar 

  17. Clarke SC, Christie P, Edwards GF: Pneumococcal disease and asplenia: The importance of vaccination. J Trauma 53(6):1037-1042, 2002

    Google Scholar 

  18. De Montalembert M, Lenoir G: Antibiotic prevention of pneumococcal infections in asplenic hosts: Admission of insufficiency. Health Bull 59(1):49-52, 2001

    Google Scholar 

  19. Hansen K, Singer DB: Asplenic-hyposplenic overhelming sepsis: Postsplenectomy sepsis revisited. Pediatr Dev Pathol 4(2):105-121, 2001

    Google Scholar 

  20. Rokicka-Milewska R: Odległ e wyniki w splenektomii w przewlekł ej samoistnej skazie mał opł ytkowej u dzieci. Pediatria Polska LIII(3):298-306, 1978 (in Polish)

    Google Scholar 

  21. Bridgen ML, Patullo A, Brown G: Pneumococcal vaccine administration associated with splenectomy; the need for improved education, documentation, and the use of a practical checklist. Am J Hematol 65(2):25-29, 2000

    Google Scholar 

  22. Doganci L, Gun H: Splenectomy and viral vaccines. Pediatr Infect Dis J 13(4):163-164, 1994

    Google Scholar 

  23. Leonard AS, Gebink GS, Baesl I: The overhelming postsplenectomy sepsis problem. World J Surg 3:423-429, 1980

    Google Scholar 

  24. Waghorn DJ: Overhelming infection in asplenic patients; current best practice preventive measures are not being followed. J Clin Pathol 54(3):214-218, 2001

    Google Scholar 

  25. Brydak LB, Rokicka-Milewska R, Machał a M, Jackowska T, Sikorska-Fic B: Immunogenicity of subunit trivalent influenza vaccine in children with acute lymphoblastic leukemia. Pediatr Infect Dis J 17:125-129, 1998

    Google Scholar 

  26. Brydak LB, Rajkowski T, Machał a M, Wçglarska J, Sieniawska M: Humoral antibody response following influenza vaccination in patients with nephrotic syndrome. Antiinfect Drugs Chemother 16(2):151-155, 1998

    Google Scholar 

  27. Brydak LB, Rokicka-Milewska R, Machał a M, Klukowska A, łaguna P, Sikorska-Fic B: Efficacy of subunit trivalent influenza vaccine in previously vaccinated children suffering from hemophilia. Clin Microbiol Infect 4:589-593, 1998

    Google Scholar 

  28. Brydak LB, Roszkowska-Blaim M, Machał a M, Leszczyńska B, Sieniawska M: Antibody response to influenza immunization in two consecutive epidemic seasons in patients with renal diseases. Vaccine 18:3280-3286, 2000

    Google Scholar 

  29. Brydak LB, Guzy J, Starzyk J, Machał a M, Góźdź S: Humoral immune response after vaccination against influenza in patients with breast cancer. Support Care Cancer 9:65-68, 2001

    Google Scholar 

  30. Brydak LB, Roszkowska-Blaim M, Machał a M, Leszczyńska B, Sieniawska M: Immunological response to influenza vaccination in children with renal failure. Nephrol Dial Transpl 16(3):643-644, 2001

    Google Scholar 

  31. Brydak LB, Machał a M, Myśliwska J, Myśliwski A, Trzonkowski P: Immune response to influenza vaccination in an elderly population. J Clin Immunol 23(3):214-222, 2003

    Google Scholar 

  32. Rokicka-Milewska R, Brydak LB, Machał a M, Klukowska A: Antibody response to influenza vaccine in children with severe and mild hemophila. Int J Pediatr Hematol/Oncol 7(1):21-27, 2000

    Google Scholar 

  33. Concepts and Procedures for Laboratory-Based Influenza Surveillance: WHO Collaborating Centers for Reference and Research on Influenza. U.S. Department of Health and Human Services, Public Health Service, Centers for Diseases Control, July 1982

  34. Aymard-Henry M, Coleman MT, Dowdle WR, Laver WG, Schild GC, Webster RG: Influenza virus neuraminidase and neuraminidase inhibition test procedures. Bull WHO 48:199-202, 1973

    Google Scholar 

  35. Douglas AR: Assay of neuraminidase (NA) activity and neuraminidase inhibition test. Report of the WHO International Collaborative Center for Reference and Research on the Influenza Virus at Mill Hill. London, National Institute for Medical Research, 1993

    Google Scholar 

  36. Committee for Proprietary Medicinal Products (CPMP): Note for guidance on harmonisation of requirements for influenza vaccines (revision). CPMP/BWP/214/96, 1997

  37. Commission of the European Communities: The rules governing medicinal products in the European community. Comm Eur Commun 3(2):93-98, 1992

    Google Scholar 

  38. Ada GL, Jones PD: The immune response to influenza infection. Curr Topics Microbiol Immunol 128:1-54, 1986

    Google Scholar 

  39. Kilbourne ED, Christenson U, Sande M: Antibody response in man to influenza virus neuraminidase following influenza. J Virol 2:761-762, 1968

    Google Scholar 

  40. Johansson BE, Moran TM, Kilbourne ED: Antigen-presenting B cells and helper T cells cooperatively mediate intravirionic antigenic competition between influenza A virus surface glycoproteins. Proc Natl Acad Sci USA 84:6869-6873, 1987

    Google Scholar 

  41. Kilbourne ED: Comparative efficacy of neuraminidase-specific and conventional influenza virus vaccines in induction of antibody to neuraminidase in humans. J Infect Dis 134:384-394, 1976

    Google Scholar 

  42. Goronzy JJ, Fulbright JW, Crowson CS, Poland GA, O'Fallon WM, Wyand CM: Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals. J Virol 75(24):12182-12187, 2001

    Google Scholar 

  43. Hurwitz ES, Haber M, Chang A, Shope T, Teo ST, Giesick JS, Ginsberg MM, Cox NJ: Studies of the 1996–1997 inactivated influenza vaccine among children attending day care: Immunologic response, protection against infection, and clinical effectiveness. J Infect Dis 182:1218-1221, 2000

    Google Scholar 

  44. Iorio AM, Zei T, Neri M, Alatri A: Possible correlation between low antigenic drift of A(H1N1) influenza viruses and induction of HI antibodies. Eur J Epidemiol 12(6):589-594, 1996

    Google Scholar 

  45. Glathe H, Bigl S, Grosche A: Comparison of humoral immune responses to trivalent influenza split vaccine in young, middle-aged and elderly people. Vaccine 11:702-705, 1993

    Google Scholar 

  46. Brydak LB, Machał a M: Humoral immune response to influenza vaccination in patients from high-risk groups. Drugs 60(1):35-53, 2000

    Google Scholar 

  47. Brydak LB, Hryniewicz HJ, Machał a M, Horban A: Humoral response to influenza vaccination in HIV-infected patients. Clin Drug Invest 17(6):441-449, 1999

    Google Scholar 

  48. Brydak LB, Calbecka M: Immunogenicity of influenza vaccine in patients with hemato-oncological disorders. Leuk Lymphoma 32(3–4):369-374, 1999

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. National Influenza Center, National Institute of Hygiene, Warsaw, Poland

    Lidia B. Brydak & Magdalena Machała

  2. Department of Pediatric Hematology and Oncology, Medical Academy, Warsaw, Poland

    Paweł Łaguna & Roma Rokicka-Milewska

Authors
  1. Lidia B. Brydak
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Magdalena Machała
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Paweł Łaguna
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Roma Rokicka-Milewska
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Lidia B. Brydak.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brydak, L.B., Machała, M., Łaguna, P. et al. Antibody Response to Influenza Vaccination in Splenectomized Patients in Poland. J Clin Immunol 24, 225–236 (2004). https://doi.org/10.1023/B:JOCI.0000025444.24160.d5

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/B:JOCI.0000025444.24160.d5

Search

Navigation