Journal of Bioenergetics and Biomembranes

, Volume 36, Issue 4, pp 381–386 | Cite as

Mitochondrial Dysfunction and Oxidative Damage in Alzheimer's and Parkinson's Diseases and Coenzyme Q10 as a Potential Treatment

  • M. Flint Beal
Article

Abstract

There is substantial evidence that mitochondrial dysfunction and oxidative damage may play a key role in the pathogenesis of neurodegenerative disease. Evidence supporting this in both Alzheimer's and Parkinson's diseases is continuing to accumulate. This review discusses the increasing evidence for a role of both mitochondrial dysfunction and oxidative damage in contributing to β-amyloid deposition in Alzheimer's disease. I also discuss the increasing evidence that Parkinson's disease is associated with abnormalities in the electron transport gene as well as oxidative damage. Lastly, I reviewed the potential efficacy of coenzyme Q as well as a number of other antioxidants in the treatment of both Parkinson's and Alzheimer's diseases.

Mitochondria oxidative damage free radicals Alzheimer's Parkinson's coenzyme Q10 

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© Springer Science+Business Media, Inc. 2004

Authors and Affiliations

  • M. Flint Beal
    • 1
  1. 1.Department of Neurology and NeuroscienceNew York Presbyterian Hospital-Weill Medical College of Cornell UniversityNew YorkNew York 10021

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