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Voltage-Operated Calcium Channel Heterogeneity in Pancreatic β Cells: Physiopathological Implications

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Abstract

Voltage-operated calcium channels play crucial roles in stimulus-secretion coupling in pancreatic β cells. A growing body of evidence indicates that these channels in β cells are heterogeneous. In particular, not all the high-threshold calcium channels expressed belong to the best known L-type. In rat insulinoma cells, for example, L, N, and P/Q-type channels are present, while in human β cells L-type and P/Q-type dominate. Where present, N-type and P/Q-type channels participate, alongside with the dominant L-type, in the control of sugar- or depolarization-induced hormone release. Distinct biophysical properties and selective modulation of the channel subtypes are likely to play important physiological roles. T-type channels are involved in beta cell apoptosis, while calcium channel autoantibodies recognizing high-threshold channels in β cells, have been described both in neurological and diabetic patients. Subtype-selective calcium channel drugs have the potential for being beneficial in beta cell pathological states.

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Authors and Affiliations

  1. Lilly Research Centre, Eli Lilly and Co., Erl Wood Manor, Windlesham, Surrey, GU20 6PH, United Kingdom

    E. Sher, F. Giovannini, A. Codignola, M. Passafaro, P. Giorgi-Rossi, S. Volsen, P. Craig, A. Davalli & P. Carrera

  2. CNR Centre of Cellular and Molecular Pharmacology, Milan, Italy

    A. Codignola & M. Passafaro

  3. S. Raffaele Hospital, Milan, Italy

    P. Giorgi-Rossi, S. Volsen, P. Craig, A. Davalli & P. Carrera

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  1. E. Sher
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  2. F. Giovannini
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Sher, E., Giovannini, F., Codignola, A. et al. Voltage-Operated Calcium Channel Heterogeneity in Pancreatic β Cells: Physiopathological Implications. J Bioenerg Biomembr 35, 687–696 (2003). https://doi.org/10.1023/B:JOBB.0000008032.49504.48

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