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Effects of PVA sponge containing chitooligosaccharide in the early stage of wound healing

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Abstract

Poly(vinyl alcohol) (PVA) sponges with different chitooligosaccharide (COS) content were prepared for wound-dressing application. The morphological structure of PVA sponges was observed by scanning electron microscopy. As the concentration of COS-loaded PVA sponge increased, the average pore size of sponge decreased and the release rate of COS from the sponge also slightly decreased. The accelerating effect of the COS-loaded PVA sponges on open wound healing in rats was investigated by macroscopic examination and measurement of wound area. The COS-loaded sponges were found to be very effective as a wound-healing accelerator in the early stage of wound healing. The wound treated with the COS-loaded PVA sponge was almost reepithelialized, granulation tissues in the wound were considerably replaced by fibrosis at 8 days after initial wounding. The COS-loaded PVA sponge was considered to be a suitable wound-healing formulation due to its easy preparation and high effectiveness.

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Authors and Affiliations

  1. Department of Textile Engineering, College of Engineering, Chungnam National University, Daejeon, 305-764, Korea

    Young You & Won Ho Park

  2. Department of Plastic and Reconstruction Surgery, College of Medicine, KyungHee University, Seoul, 130-702, Korea

    Bub Min Ko

  3. Department of Oral Biochemistry, College of Dentistry, Seoul National University, Seoul, 110-749, Korea

    Byung-Moo Min

Authors
  1. Young You
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  2. Won Ho Park
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  3. Bub Min Ko
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  4. Byung-Moo Min
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Correspondence to Won Ho Park.

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You, Y., Park, W.H., Ko, B.M. et al. Effects of PVA sponge containing chitooligosaccharide in the early stage of wound healing. Journal of Materials Science: Materials in Medicine 15, 297–301 (2004). https://doi.org/10.1023/B:JMSM.0000015491.91918.64

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  • DOI: https://doi.org/10.1023/B:JMSM.0000015491.91918.64

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