Abstract
Sulfonic acid derivatives of dibenzo-18-crown-6 (DB18C6) have been shown to induce formation of ion channels permeable to monovalent cations in bilayer lipid membranes (BLM). Some electric characteristics of channels have been studied by means of the voltage clamp method. Channels displayed little interionic discrimination. The voltage dependence as well as the multiple state behaviors of the channels functioning was observed. The channels formation has been shown to be dependent on pH of bath solutions and on the presence of bivalent cations in them. The channels supposed to be formed from aggregates of complexes associates assembled in aqueous salt solutions.
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Yarishkin, O., Tashmukhamedova, A., Mirkhodjaev, U. et al. Characteristics of Single Ionic Channels Induced by Sulfonic Acid Derivatives of Dibenzo-18-Crown-6 in Bilayers. Journal of Inclusion Phenomena 49, 139–144 (2004). https://doi.org/10.1023/B:JIPH.0000031127.96079.62
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DOI: https://doi.org/10.1023/B:JIPH.0000031127.96079.62