Abstract
Aim of the study: to evaluate the impact of dual defibrillator implantation on quality of life and resource utilization in patients with drug refractory atrial fibrillation (AF) without prior ventricular arrhythmias.
Methods: Forty patients (28 M, mean age 64 ± 10) received a dual defibrillator Medtronic 7250. AF was persistent in 60% and paroxysmal in 40%.
Results: The follow-up lasted 15 ± 4 months (range 12–30). Eighty-five percent of patients had atrial tachyarrhythmia recurrences. Among 1366 treated episodes, overall success rate was 60.1% for antitachy pacing and 88.2% for atrial shock. Within one year after implant, arrhythmia related hospitalization number decreased from 1.5 ± 2.0 to 0.4 ± 0.8 (p < 0.01) and 77% of patients were free from hospitalization. As regard to quality of life, Symptom Checklist/Frequency and Severity Scale improved after implant for all items and SF-36 questionnaire showed significant improvements in physical activities because of health problems and social activities. The patients assigned to early delivery of atrial shock after AF onset, when compared with the patients who did not accept atrial shock, showed a significant reduction of AF burden, a higher reduction of hospitalization number and a greater improvement of quality of life.
Conclusion: Dual defibrillator improved quality of life and decreased resource utilization in patients with drug refractory AF. Early delivering of atrial shock seems to be the most effective option.
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Wolf PA, Mitchell JB, Baker CS, Kannel WB, D'Agostino RB. Impact of atrial fibrillation on mortality, stroke and medical costs. Arch Intern Med 1998;158:229-234.
Kannel WB, Abbot RD, Savage DD, Nc Namara PM. Epidemiologic features of chronic atrial fibrillation. New Engl J Med 1982;306:1018-1022.
Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation as an independent risk factor for stroke: The Framingham study. Stroke 1991;22:983-988.
Hamer ME, Blumenthal JA, Mc Carthy EA, Phillips BG, Pritchett ELC. Quality of life assessment in patients with paroxysmal atrial fibrillation or paroxysmal supraventricular tachycardia. Am J Cardiol 1994;74:826-829.
Suttorp MJ, Kingma JH, Koomen EM, van't Hof A, Tijssen JG, Li. Recurrence of paroxysmal atrial fibrillation or flutter after successful cardioversion in patients with normal left ventricle function. Am J Cardiol 1993;71:710-713.
Santini M, Alexidou G, Ansalone G, Cacciatore G, Cini R, Turitto G. Relation of prognosis in sick sinus syndrome to age, conduction defects and modes of permanent cardiac pacing. Am J Cardiol 1990;65:729-735.
Andersen HR, Nielsen JC, Thomsen PE, Thuesen L, Mortensen PT, Vesterlund T, Pedersen AK. Long-term follow up of patients from a randomised trial of atrial versus ventricular pacing for sick-sinus syndrome. Lancet 1997;350:1210-1216.
Santini M, Ricci R, Puglisi A, Mangiameli S, Proclemer A, Menozzi C, De Fabrizio G, Leoni G, Lisi F, De Sata F. Long-term haemodynamic and antiarrhythmic benefits of DDIR versus DDI pacing mode in sick sinus syndrome and chronotropic incompetence. G Ital Cardiol 1997;27:892-900.
Bellocci F, Spampinato A, Ricci R, Puglisi A, Capucci A, Dini P, Boriani G, Botto G, Curnis A, Moracchini PV, Nicotra G, Lisi F, Nigro P. Antiarrhythmic benefits of dual chamber stimulation with rate-response in patients with paroxysmal atrial fibrillation and chronotropic incompetence. A prospective multicentre study. Europace 1999;1:220-225.
Ricci R, Santini M, Puglisi A, Azzolini P, Capucci A, Pignalberi C, Boriani G, Botto GL, Spampinato A, Bellocci F, Proclemer A, Grammatico A, de Seta F. Impact of consistent atrial pacing algorithm on premature atrial complexe number and paroxysmal atrial fibrillation recurrences in brady-tachy syndrome: A randomized prospective cross over study. J Interv Card Electrophysiol 2001;5:33-44.
Baeriswyl G, Zimmerman M, Adamec R. Efficacy of rapid atrial pacing for conversion of atrial flutter in medically treated patients. Clin Cardiol 1994;17:246-250.
Santini M, Pandozi C, Altamura G, Gentilucci G, Villani M, Scianaro MC, Castro A, Ammirati F, Magris B. Single shock endocavitary low energy intracardiac cardioversion of chronic atrial fibrillation. J Interv Card Electrophysiol 1999;3:45-51.
Wellens HJ, Lau CP, Luderitz B, Akhtar M, Waldo AL, Camm AJ, Timmermans C, Tse HF, Jung W, Jordaens L, Ayers G. Atrioverter: An implantable device for the treatment of atrial fibrillation. Circulation 1998;98:1651-1656.
Adler SW, Wolpert C, Warman EN, Musley SK, Koehler JL, Euler DE for the Worldwide Jewel AF Investigators. Efficacy of pacing therapies for treating atrial tachyarrhythmias in patients with ventricular arrhythmias receiving a dual-chamber implantable cardioverter defibrillator. Circulation 2001;104:887-892.
Friedman PA, Dijkman B, Warman EN, Xia HA, Mehra R, Stanton MS, Hammill SC. for the Worldwide Jewel AF Investigators. Atrial therapies reduce atrial arrhythmia burden in defibrillator patients. Circulation 2001;104:1023-1028.
Ricci R, Pignalberi C, Disertori M, Capucci A, Padeletti L, Botto G, Toscano S, Miraglia F, Grammatico A, Santini M. Efficacy of a dual chamber defibrillator with atrial antitachycardia functions in treating spontaneous atrial tachyarrhythmias in patients with life-threatening ventricular tachyarrhythmias. Eur Heart J 2002;23:1471-1479.
Disertori M, Padeletti L, Santini M, et al. on behalf of the AT500 Italian Registry Investigators: Antitachycardia pacing therapies to terminate atrial tachyarrhythmias: The AT500 Italian Registry. Eur Heart J 2001;3(Suppl. P):P16-P24.
Jenkins LS, Bubien RS. Quality of life in patients with atrial fibrillation. Cardiology Clinics 1996;14:597-606.
Ware JE. The SF-36 Health Survey Manual and Interpretation Guide. Boston, MA, The Health Institute, New England Medical Center, 1993.
Ware JE, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I: Conceptual framework and item selection. Medical Care 1992;30:473-483.
McHorney CA, Ware JE, Raczek AE. The MOS 36-item short-form health (SF-36). II: Psychometric and clinical tests of validity in measuring physical and mental health conditions. Medical Care 1993;81:247-263.
McHorney CA, Ware JE, Lu JFR, Sherbourne CD. The MOS 36-item short-form health (SF-36), III: Tests of data quality, scaling assumptions, and reliability across diverse patient groups. Medical Care 1994;82:40-66.
Bubien RS, Kay GN, Jenkins LS. Test Specifications for Symptom Checklist: Frequency and Severity. Milwaukee, University of Wisconsin-Milwaukee, 1993.
Liang KY, Zeger SL. Longitudinal data analysis using generalized linear models. Biometrika 1986;73:13-22.
Gold MR, Sulke N, Schwartzman DS, Mehra R, Euler DE, for the Worldwide Jewel AF-only Investigators. Clinical experience with a dual chamber implantable cardioverter defibrillator to treat atrial tachyarrhythmias. J Cardiovasc Electrophysiol 2001;12:1247-1253.
Luderitz B, Jung W. Quality of life in atrial fibrillation. J Interv Card Electrophysiol 2000;4:201-209.
Dorian P, Jung W, Newman D, Paquette M, Wood K, Ayers GM, Camm J, Akhtar M, Luderitz B. The impairment of health-related quality of life in patients with intermittent atrial fibrillation: Implications for the assessment of investigational therapy. J Am Coll Cardiol 2000;36:1303-1309.
Lonnerholm S, Blomstrom P, Nilsson L, Oxelbark S, Jideus L, Blomstrom-Lundqvist C. Effects of the Maze operation on health-related quality of life in patients with atrial fibrillation. Circulation 2000;101:2607-2611.
Brignole M, Gianfranchi L, Menozzi C, Bottoni N, Bollini R, Lolli G, Oddone D, Gaggioli G. Influence of atrioventricular junction radiofrequency ablation in patients with chronic atrial fibrillation and flutter on quality of life and cardiac performance. Am J Cardiol 1994;74:242-246.
Brignole M, Gianfranchi L, Menozzi C, Lolli G, Paparella N, Acquarone S. Assessment of atrioventricular junction ablation and DDDR mode-switching pacemaker versus pharmacological treatment in patients with severely symptomatic paroxysmal atrial fibrillation. A randomized controlled study. Circulation 1997;96:2617-2624.
Fitzpatrick AP, Kourouyan HD, Siu A, Lee RJ, Lesh MD, Epstein LM, Griffin JC, Scheinman MM. Quality of life and outcomes after radiofrequency His-bundle catheter ablation and permanent pacemaker implantation: Impact of treatment in paroxysmal and established atrial fibrillation. Am Heart J 1996;131:499-507.
Wijffels MCEF, Kirchhof CJHJ, Dorland RD, Allessie MA. Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats. Circulation 1995;92:1954-1968.
Timmermans C, Levy S, Ayers GM, for the Metrix Investigators. Spontaneous episodes of atrial fibrillation after implantation of the Metrix atrioverter: Observations on treated and nontreated episodes. J Am Coll Cardiol 2000;35:1428-1433.
Tse HF, Lau CP, Yu CM, Lee KL, Michaud GF, Knight BP, Morady F, Strickberger SA. Effect of the implantable atrial defibrillator on the natural history of atrial fibrillation. J Cardiovasc Electrophysiol 1999;10:1200-1209.
Gillis AM, Wyse G, Connolly SJ, Dubuc M, Philippon F, Yee R, Lacombe P, Rose MS, Kerr CD. for the Atrial Pacing Periablation for Paroxysmal Atrial Fibrillation (PA3) Study Investigators: Atrial pacing periablation for prevention of paroxysmal atrial fibrillation. Circulation 1999;99;2553-2558.
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Ricci, R., Quesada, A., Pignalberi, C. et al. Dual Defibrillator Improves Quality of Life and Decreases Hospitalizations in Patients with Drug Refractory Atrial Fibrillation. J Interv Card Electrophysiol 10, 85–92 (2004). https://doi.org/10.1023/B:JICE.0000011490.32755.40
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DOI: https://doi.org/10.1023/B:JICE.0000011490.32755.40