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Model for Transition from Waves to Synchrony in the Olfactory Lobe of Limax

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Abstract

A biophysical model for the interactions between bursting (B) cells and nonbursting (NB) cells in the procerebral lobe of Limax is developed and tested. Phase-sensitivity of the NB cells is exhibited due to the strong inhibition from the rhythmically bursting B cells. Electrical and chemical junctions coupled with a parameter gradient lead to sustained periodic waves in the lobe. Excitatory interactions between the NB cells, which rarely fire, lead to stimulus evoked synchrony in the lobe oscillations. A novel calcium current is suggested to explain the effects of nitric oxide (NO) on the lobe. Gap junctions are shown both experimentally and through simulations to be required for the oscillating field potentials.

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Authors and Affiliations

  1. Department of Mathematics, University of Pittsburgh, Pittsburgh, PA, 15260, USA

    Bard Ermentrout

  2. Division of Biological Sciences, University of California, San Diego, 2218 Bonner Hall 9500 Gilman Drive, La Jolla, CA, 92093-0368, USA

    Jing W. Wang

  3. Center for Neurobiology and Behavior, Columbia University, New York, NY, 10032, USA

    Jorge Flores

  4. Monell Chemical Senses Center, 3500 Market St., Philadelphia, PA, 19104, USA

    Alan Gelperin

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  1. Bard Ermentrout
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Ermentrout, B., Wang, J.W., Flores, J. et al. Model for Transition from Waves to Synchrony in the Olfactory Lobe of Limax. J Comput Neurosci 17, 365–383 (2004). https://doi.org/10.1023/B:JCNS.0000044877.21949.44

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