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Ferritin, the path of iron into the core, as seen by Mössbauer spectroscopy

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Abstract

Ferritin, the ubiquitous iron storage protein, has been widely studied by a variety of techniques. The paper reviews Mössbauer studies on horse spleen and human recombinant ferritins, which helped to reveal the pathway iron follows from its uptake by the protein from a solution of Fe2SO4 to the building of the iron core of ferritin. Five different Fe(III) species and two Fe(II) species were observed, among them a peroxo-bridged and an oxo-bridged dimer, a monomer, small iron clusters and large iron aggregates. Transfer of iron between ferritin molecules was established.

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References

  1. Bothwell, T. H., Charlton, R. W., Cook, J. D. and Finch, C. A., In:Iron Metabolism in Man, Blackwell, Oxford, 1979, p. 1.

    Google Scholar 

  2. Harrison, P. M. and Arosio, P.,BBA 1275 (1996), 161.

    Article  Google Scholar 

  3. Chasteen, N. D. and Harrison, P. M.,J. Struct. Biol. 126 (1999), 182.

    Article  Google Scholar 

  4. Lawson, D. M., Artymiuk, P. J., Yewdall, S. J., Smith, J. M. A., Livingstone, J. C., Treffry, A., Luzzago, A., Levy, S., Arosio, P., Cesareni, C., Thomas, C. D., Shaw, W. V. and Harrison, P. M.,Nature 349 (1991), 541.

    Article  ADS  Google Scholar 

  5. Hudson, A. J., Andrews, S. C., Hawkins, C., Williams, J. M., Izuhara, M., Meldrum, F. C., Mann, S., Harrison, P. M. and Guest, J. R.,Eur. J. Biochem. 218 (1993), 985.

    Article  Google Scholar 

  6. Cowley, J. M., Janney, D. E., Gerkin, R. C. and Buseck, P. R.,J. Struct. Biology 131 (2000), 210.

    Article  Google Scholar 

  7. Wade, V. J., Treffry, A., Laulhere, J. P., Bauminger, E. R., Cleton, M. I., Mann, S., Brian, J. F. and Harrison, P. M.,BBA 1161 (1993), 91.

    Google Scholar 

  8. Hempstead, P. D., Yewdall, S. J., Fernie, A. R., Lawson, D. M., Artymiuk, P. J., Rice, D. W., Ford, G. C. and Harrison, P. M.,J. Mol. Biol. 268 (1997), 424.

    Article  Google Scholar 

  9. Santambrogio, P., Levi, S., Cozzi, C., Corsi, B. and Arosio, P.,Biochem. J. 314 (1996), 9.

    Google Scholar 

  10. Treffry, A. and Harrison, P. M.,J. Inorg. Biochem. 21 (1984), 9.

    Article  Google Scholar 

  11. Le Brun, N. E., Wilson, M. T., Guest, S. C., Harrison, P. M., Thomson, A. J. and Moore, G. R.,FEBS Lett. 333 (1993), 197.

    Article  Google Scholar 

  12. Chasteen, N. D., Antanaitis, B. C. and Aisen, P.,J. Biol. Chem. 260 (1985), 2926.

    Google Scholar 

  13. Moënne-Loccoz, P., Krebs, C., Herlihy, K., Edmondson, D. E., Theil, E. C., Huynh, B. H. and Loehr, T. M.,Biochemistry 38 (1999), 5290.

    Article  Google Scholar 

  14. Yang, C., Meagher, A., Huynh, B. H., Sayers, D. E. and Theil, E. C.,Biochemistry 26 (1987), 497.

    Article  Google Scholar 

  15. Treffry, A., Harrison, P. M., Luzzago, A. and Cesareni, G.,FEBS Lett. 247 (1989), 268.

    Article  Google Scholar 

  16. Treffry, A., Zhao, Z. W., Quail, M. A., Guest, J. R. and Harrison, P. M.,Biochemistry 36 (1997), 432.

    Article  Google Scholar 

  17. Bauminger, E. R., Harrison, P. M., Nowik, I. and Treffry, A.,Biochemistry 28 (1989), 5486.

    Article  Google Scholar 

  18. Morup, S. and Knudsen, J. E.,Acta Chim. Hung. 121 (1986), 147.

    Google Scholar 

  19. Bancroft, G. M., Maddock, A. G. and Randl, R. P.,J. Chem. Soc. A (1968), 2939.

  20. Mørup, S., Dumesic, J. A. and Tøpse, H., In: R. L. Cohen (ed.),Application of Mössbauer Spectroscopy, Vol. 2, Academic Press, NY, 1980, p. 1.

    Google Scholar 

  21. Boas, J. F. and Windows, B.,Aust. J. Phys. 19 (1966), 573.

    ADS  Google Scholar 

  22. Frankel, R. B., Papaefthymiou, G. C. and Watt, G. D.,Hyp. Interact. 33 (1987), 233.

    Article  ADS  Google Scholar 

  23. Bauminger, E. R., Harrison, P. M., Hechel, D., Nowik, I. and Treffry, A.,Biochim. Biophys. Acta 1118 (1991), 48.

    Google Scholar 

  24. Bauminger, E. R., Nowik, I., Harrison, P. M. and Treffry, A.,Hyp. Interact. 42 (1988), 873.

    Article  ADS  Google Scholar 

  25. Levi, S., Luzzago, A., Cesareni, G. C., Cozzi, A., Franceschinelli, F., Albertini, A. and Arosio, P.,Biol. Chem. 263 (1988), 18086.

    Google Scholar 

  26. Lawson, D. M., Treffry, A., Artymiuk, P. J., Harrison, P. M., Yewdall, S. J., Luzzago, A., Cesareni, G., Levy, S. and Arosio, P.,FEBS Lett. 254 (1989), 207.

    Article  Google Scholar 

  27. Bauminger, E. R., Harrison, P. M., Hechel, D., Hodson, N. W., Nowik, I., Treffry, A. and Yewdall, S. J.,Biochem. J. 296 (1993), 709.

    Google Scholar 

  28. Levi, S., Luzzago, A., Franceschinelli, F., Santambrogio, P., Cesareni, G. and Arosio, P.,Biochem. J. 264 (1989), 381.

    Google Scholar 

  29. Levi, S., Yewdall, J., Harrison, P. M., Santambrogio, P., Cozzi, A., Rovida, E., Albertini, A. and Arosio, P.,Biochem. J. 288 (1992), 591.

    Google Scholar 

  30. Macara, I. G., Hoy, T. G. and Harrison, P. M.,Biochem. J. 126 (1972), 151.

    Google Scholar 

  31. Treffry, A., Bauminger, E. R., Hechel, D., Hodson, N. W., Nowik, I., Yewdall, S. J. and Harrison, P. M.,Biochem. J. 296 (1993), 721.

    Google Scholar 

  32. Levi, S., Santambrogio, P., Corsi, B., Cozzi, A. and Arosio, P.,Biochem. J. 317 (1996), 467.

    Google Scholar 

  33. Bou-Abdallah, F., Arosio, P., Santambrogio, P., Yang, X., Janus-Chandler, C. and Chasteen, N. D.,Biochemistry 41 (2002), 11184.

    Article  Google Scholar 

  34. Cavallo, S., Giampiero, M., Simontta, S., Rosato, N., Finazzi-Agro, A. and Chiancone, E.,Protein Sci. 7 (1998), 427.

    Article  Google Scholar 

  35. Treffry, A., Hirzmann, J., Yewdall, S. J. and Harrison, P. M.,FEBS. Lett. 302 (1992), 108.

    Article  Google Scholar 

  36. Bauminger, E. R., Harrison, P. M., Hechel, D., Nowik, I. and Treffry, A.,Proc. R. Soc. Lond. B 244 (1991), 211.

    Article  ADS  Google Scholar 

  37. Bauminger, E. R., Harrison, P. M., Hechel, D., Nowik, I. and Treffry, A.,Hyp. Interact. 71 (1992), 1287.

    Article  ADS  Google Scholar 

  38. Bauminger, E. R., Treffry, A., Hudson, A. J., Hechel, D., Hodson, N. W., Andrews, S. C., Levi, S., Nowik, I., Arosio, P., Guest, J. R. and Harrison, P. M.,Biochem. J. 302 (1994), 813.

    Google Scholar 

  39. Treffry, A., Zhao, Z., Quail, A., Guest, J. R. and Harrison, P. M.,Biochemistry 34 (1995), 15204.

    Article  Google Scholar 

  40. Waldo, G. S., Ling, J., Sanders-Loehr, J. and Theil, E. C.,Science 259 (1993), 796.

    Article  ADS  Google Scholar 

  41. Pereira, A. S., Small, W., Krebs, C., Tavares, P., Edmondson, D. E., Theil, E. C. and Huynh, B. H.,Biochemistry 37 (1998), 9871.

    Article  Google Scholar 

  42. Bou-Abdallah, F., Papaefthymiou, G. C., Scheswohl, D. M., Stanga, S. D., Arosio, P. and Chasteen, N. D.,Biochem. J. 364 (2002), 57.

    Google Scholar 

  43. Zhao, Z., Treffry, A., Quall, M. A., Guest, J. R. and Harrison, P. M.,J. Chem. Soc. Dalton Trans. (1997), 3977.

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Authors and Affiliations

  1. Racah Institute of Physics, The Hebrew University, 91904, Jerusalem, Israel

    E. R. Bauminger

  2. Department of Molecular Biology and Biotechnology, Krebs Institute for Biomolecular Research, S10 2TN, Sheffield, UK

    P. M. Harrison

Authors
  1. E. R. Bauminger
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  2. P. M. Harrison
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On the occasion of the 80th birthday of Hendrik de Waard

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Bauminger, E.R., Harrison, P.M. Ferritin, the path of iron into the core, as seen by Mössbauer spectroscopy. Hyperfine Interact 151, 3–19 (2003). https://doi.org/10.1023/B:HYPE.0000020401.01552.56

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