Abstract
Ascendancy therapy with histamine had a distinct clinical effect and caused stable remission in patients with infectious allergic bronchial asthma. Therapy normalized not only histamine release but also the balance of all components of the immune system. Beginning from minimum doses of histamine, gradual adaptation of the immune system was observed and normalized the immune response. To improve the clinical efficiency, it is important to control the increase of the prescribed doses of histamine. A simple test for a change in granulocyte migration to the oral cavity was proposed for this purpose. The paper discusses the probability that common mechanisms underlie immunotherapy in specific chronic allergy, ascendancy therapy with histamine in intrinsic allergy, and dosed immunotherapy in chronic inflammatory disorders.
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Lebedev, K.A., Ponyakina, I.D. Physiological Mechanisms of Histamine-Induced Hyposensibilization in Infectious Allergic Bronchial Asthma. Human Physiology 30, 445–451 (2004). https://doi.org/10.1023/B:HUMP.0000036340.34954.f4
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DOI: https://doi.org/10.1023/B:HUMP.0000036340.34954.f4