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The role of glycosphingolipids in HIV signaling, entry and pathogenesis

Glycoconjugate Journal volume 20, pages 213–222 (2003)Cite this article

Abstract

Although HIV uses CD4 and coreceptors (CCR5 and CXCR4) for productive infection of T cells, glycosphingolipids (GSL) may play ancillary roles in lymphoid and non-lymphoid cells. Interactions of the HIV Envelope Glycoprotein (Env) with GSL may help HIV in various steps of its pathogenesis. Physical-chemical aspects of the interactions between HIV Env and GSL leading to CD4-dependent entry into lymphocytes, the role of GSL in HIV transcytosis, and CD4-independent entry into non-lymphoid cells are reviewed. An overview of signaling properties of HIV receptors is provided with some speculation on how GSL may play a role in these events by virtue of being in membrane rafts. Finally, we summarize how interactions between HIV and coreceptors leading to signaling and/or fusion can be analyzed by the use of various tyrosine kinase and cytoskeletal inhibitors. Published in 2004.

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Affiliations

  1. Laboratory of Experimental and Computational Biology, Center for Cancer Research, NCI-Frederick, National Institutes of Health, Frederick, MD

    Mathias Viard, Satinder S. Rawat, Anu Puri & Robert Blumenthal

  2. Hematology-Oncology, Istituto Superiore di Sanita, Rome, Italy

    Isabella Parolini, Katia Fecchi & Massimo Sargiacomo

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  1. Mathias Viard
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  2. Isabella Parolini
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  7. Robert Blumenthal
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Correspondence to Robert Blumenthal.

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Viard, M., Parolini, I., Rawat, S.S. et al. The role of glycosphingolipids in HIV signaling, entry and pathogenesis. Glycoconj J 20, 213–222 (2003). https://doi.org/10.1023/B:GLYC.0000024253.48791.d9

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  • Issue Date:

  • DOI: https://doi.org/10.1023/B:GLYC.0000024253.48791.d9

  • HIV infection
  • glycosphingolipids
  • PPMP
  • membrane fusion
  • membrane rafts
  • transcytosis
  • CD4
  • chemokine receptors
  • signal transduction
  • HIV pathogenesis
  • cytoskeleton