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Regulation of gonadotropin subunit genes expression by 11-ketotestosterone during early spermatogenesis in male red seabream, Pagrus major

Fish Physiology and Biochemistry volume 28, pages 111–112 (2003)Cite this article

Abstract

To examine the roles of gonadal steroids in the regulation of expression of gonadotropin subunit genes, male red seabream were gonadectomized and a sub-group was treated with 11-ketotestosterone (11-KT). Castration of males during the early stage of spermatogenesis elicited a significant increase in FSHβ mRNA levels, which was prevented by 11-KT replacement. By contrast, LHβ mRNA levels were not changed by castration or 11-KT replacement. In addition, administration of 11-KT to sham-operated males suppressed the steady-state FSHβ and LHβ mRNA levels. These results indicate that 11-KT may function as a negative feedback regulator of FSHβ gene expression, and may act through the testis to down-regulate LHβ mRNA levels in male red seabream during this period.

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References

  • Antonopoulou, E., Swanson, P., Mayer, I. and Borg, B. 1999. Feedback control of gonadotropins in Atlantic salmon, Salmo salar, male parr. II. Aromatase inhibitor and androgen effects. Gen. Comp. Endocrinol. 114. 142–150.

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Authors and Affiliations

  1. Department of Animal and Marine Bioresource Sciences, Kyushu University, Fukuoka, 812-8581, Japan

    S. Yamaguchi & M. Matsuyama

  2. Fisheries Research Agency, Inland Station, National Research Institute of Aquaculture, Tamaki, Mie, 519-0423, Japan

    K. Gen

  3. Fisheries Research Agency, National Research Institute of Aquaculture, Nansei, Mie, 516-0193, Japan

    K. Okuzawa

  4. Department of Aquatic Bioscience, Tokyo University of Fisheries, Minato, Tokyo, 108-8477, Japan

    N. Kumakura

  5. Department of Biological Production and Environmental Science, Miyazaki University, Miyazaki, 889-2192, Japan

    H. Kagawa

Authors
  1. S. Yamaguchi
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  2. K. Gen
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  3. K. Okuzawa
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  4. N. Kumakura
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  5. H. Kagawa
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  6. M. Matsuyama
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Yamaguchi, S., Gen, K., Okuzawa, K. et al. Regulation of gonadotropin subunit genes expression by 11-ketotestosterone during early spermatogenesis in male red seabream, Pagrus major . Fish Physiology and Biochemistry 28, 111–112 (2003). https://doi.org/10.1023/B:FISH.0000030494.13499.06

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  • DOI: https://doi.org/10.1023/B:FISH.0000030494.13499.06

Keywords

  • Gene Expression
  • Steroid
  • mRNA Level
  • Negative Feedback
  • Feedback Regulator

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