Abstract
Background: Population-based estimates of hospitalization rates for varicella provide data of the severe and costly end of this disease.
Objective: To estimate the annual burden of hospitalization due to primary varicella in the 17 Autonomous Regions of Spain.
Methods: Data were obtained from the national surveillance system for hospital data and comprises all hospital discharges for varicella reported during the 1995–2000 period.
Results: The overall incidence of hospitalizations was 2.7 per 100,000 persons per year (ranging from 3.2 in Navarra to 1.5 in the Canary Islands). Forty-eight deaths were reported during the period. Each year varicella was responsible for 3017 days of hospitalization in persons ≤ 10 years of age and 3333days in persons > 10 years of age. The annual cost of these hospitalizations was 1.2 million and more than 500.000 euros for persons ≤ 10 years and > 10 years of age, respectively.
Conclusion: Varicella is associated to a severe morbidity in children, adolescents and adults in Spain. The burden of varicella is likely to be potentially reduced by effective immunization programs.
Similar content being viewed by others
References
Lin F, Hadler JL. Epidemiology of primary varicella and herpes zoster hospitalisations: The pre-vaccination era. J Infect Dis 2000; 181: 1897-1905.
Choo PW, Donahue JG, Manson JE, Platt R. The epidemiology of varicella and its complications. J Infect Dis 1995; 172: 706–712.
Lieu TA, Black SB, Riejer N, Ray PP, Lewis EM, Shinefield HR. The cost of childhood chickenpox parent's a perspective. Pediatr Infect Dis J 1994; 13: 173–177.
Peterson CL, Mascola L, Chao SM, et al. Children hospitalised for varicella: A prevaccine review. J Pediatr 1996; 129: 529–536.
American Academy of Pediatrics. The 1997 red book. Elk Grove Village, Illinois: American Academy of Pediatrics, 1997.
Lieu TA, Cochi SL, Black SB, et al. Cost-effectiveness of a routine varicella vaccination program for US children. JAMA 1994; 271: 375–381.
Huse DM, Meissner HC, Lacey MJ, Oster G. Childhood vaccination against chickenpox: An analysis of benefits and costs. J Pediatr 1994; 124: 869-874.
Centers for Disease Control. Summary of notifiable diseases, United States, 1994. MMWR 1995; 43(53): 1–55.
Visser LE, Cano Portero R, Gay NJ, Martínez Navarro JF. Impact of rotavirus disease in Spain: An estimate of hospital admissions due to rotavirus. Acta Paediatr1999; 426(Suppl): 72–76.
Ministerio de Sanidad y Consumo. Clasificación Internacional de Enfermedades 9 Revisión, Modificación Clínica (9th International Classification of Diseases, Clinical Modification), 1994.
Pizarro A, Pachón I. Situación actual de tétanos y tos ferina. Bol Epidemiol Sem 1998; 6: 297-308. (Current situation of Tetanus and Pertussis.)
Reverte-Cejudo D, Sá nchez-Bayle M. Devolving health services to Spain's autonomous regions. Br Med J 1999; 318: 1204-1205.
F. Favereau & Associates (eds), Healthcare handbook, Spain, France: Lagon, 1998-1999; 4(2): 51–124.
Diez-Domingo J, Ridao M, Latour J, Ballester A, Morant A. A cost benefit analysis of routine varicella vaccination in Spain. Vaccine 1999; 17: 1306-1311.
Coplan P, Black S, Rojas C, et al. Incidence and hospitalization rates of varicella and herpes zoster before varicella vaccine introduction: A baseline assessment of the shifting epidemiology of varicella disease. Pediatr Infect Dis J 2001;20: 641-645.
Centro Nacional de Epidemiología. Enfermedades de declaración obligatoria. España. 1995 y 1996. Bol Epidemiol Semanal 1997; 5: 2. (Compulsory Reported Diseases, Spain, 1995 and 1996).
Centro Nacional de Epidemiología. Enfermedades de declaración obligatoria. Incidencia notificada en España. 1996 y 1997. Bol Epidemiol Semanal 1998; 6: 2. (Compulsory Reported Diseases. Reported incidence in Spain 1996 and 1997).
Centro Nacional de Epidemiología. Enfermedades de declaración obligatoria. Incidencia notificada en España. 1997 y 1998. Bol Epidemiol Semanal 1999; 7: 2. (Compulsory Reported Diseases Reported incidence in Spain 1997 and 1998).
Centro Nacional de Epidemiología. Comentario epidemiológico de las Enfermedades de declaración obligatoria. España. Año 1999. Bol Epidemiol Semanal 2000; 8: 2. (Epidemiological comments on Compulsory Reported Diseases Reported. Spain, 1999).
Centro Nacional de Epidemiología. Comentario epidemiológico de las Enfermedades de declaración obligatoria. España. Año 2000. Bol Epidemiol Semanal 2001; 9: 102. (Epidemiological comments on Compulsory Reported Diseases Reported. Spain, 2000).
Fairley CK, Miller E. Varicella-zoster virus epidemiology; a changing scene? J Infect Dis 1996; 174(Suppl 3): S314–S319.
Varughese PV. Chickenpox in Canada, 1924-1987. Can Med Assoc J 1988; 138: 133-134.
23. Choo PW, Donahue JG, Manson JE, Platt R. The epidemiology of varicella and its complications. J Infect Dis 1995; 172: 706-712.
24. Yawn BP, Yawn RA, Lydick E. Community impact of childhood varicella infection. J Pediatr 1997; 130: 759-765.