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Risk Factors for Hepatitis C Virus Infection among Blood Donors in Georgia

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Abstract

Background: Growing awareness about the importance of blood safety for controlling the transmission of hepatitis C virus (HCV) has helped to decrease the spread of this virus in many settings. This study was conducted in order to evaluate potential risk factors for HCV infection among blood donors in Georgia. Methods: The study population consisted of 553 blood donors in three major Georgian cities; Tbilisi, the capital city and Batumi and Poti, naval port cities. Risk factors were examined using a behavior questionnaire. All blood samples were initially tested using 3rd generation anti-HCV enzyme-linked immunosorbent assays and confirmed using recombinant immunoblot assays and nucleic acid testing. Results: Forty-three blood donors, 7.8%, were confirmed HCV positive. Significant risk factors included: drug injection ever (OR: 42; 95% CI: 3.2–550.7); history of hepatitis (OR: 25.9; 95% CI: 4.6–145.5); history of a previous surgical procedure (OR: 148.4; 95% CI: 26.9–817.4); blood transfusion (OR: 25.9; 95% CI: 3.2–210.9). Conclusions: This study found a very high prevalence of HCV among blood donors in Georgia. The main risk factor for HCV infection in this population of blood donors was previous contact with contaminated blood or blood products. Reliable screening of donors and their blood is critical for controlling the further spread of HCV in Georgia.

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Authors and Affiliations

  1. Departments of Epidemiology and International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA

    Nickolas Zaller

  2. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street Room, E7132, Baltimore, MD, 21205, USA

    Kenrad E. Nelson

  3. Infectious Diseases, AIDS and Clinical Immunology Research Center, Tbilisi

    Malvina Aladashvili, Nino Badridze & Tengiz Tsertsvadze

  4. Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA

    Carlos del Rio

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  1. Nickolas Zaller
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  2. Kenrad E. Nelson
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  3. Malvina Aladashvili
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  4. Nino Badridze
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  5. Carlos del Rio
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  6. Tengiz Tsertsvadze
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Correspondence to Kenrad E. Nelson.

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Zaller, N., Nelson, K.E., Aladashvili, M. et al. Risk Factors for Hepatitis C Virus Infection among Blood Donors in Georgia. Eur J Epidemiol 19, 547–553 (2004). https://doi.org/10.1023/B:EJEP.0000032352.29173.78

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  • DOI: https://doi.org/10.1023/B:EJEP.0000032352.29173.78

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