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Firm measures are required to effect any significant decrease in the Japanese age-adjusted mortality rate from malignant neoplasms for the 21st century

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Abstract

The Japanese have the longest lifespan worldwide, but this has been mostly due to reductions in the mortality rates from diseases other than malignant neoplasms. Changes in the age-adjusted mortality rates (AMRs) for malignant neoplasms in Japan from 1950 to 2000 are analyzed to elucidate the overall trend. The overall AMRs for all malignant neoplasms in men increased from 1950 to 2000, and decreased slowly in women during the same period. Changes since 1990 have been small in both genders, but show a hopeful trend towards a decrease in the total AMR since 1995. These trends reflect a balance between the decreased AMR from gastric (both male and female) and uterine cancers and increases in many other malignant neoplasms. However, in the period 1990–2000, the decrease in the AMR from gastric and uterine cancers has shown a trend towards leveling off. Therefore, improving the trend towards reductions in cancer incidence and mortality in the 21st century and beyond will depend on achieving changes in other cancer sites, which can only be realized through the twofold approach of preventative medicine and research as well as improvements in the levels of diagnosis and therapy. Much more emphasis must therefore be placed on primary prevention, in particular on anti-smoking campaigns, as well as stepping-up research into the etiology of, and novel treatments for other malignant neoplasms, especially colorectal and breast cancers.

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References

  1. Bailar III JC, Smith EM. Progress against cancer? N Engl J Med 1986; 314: 1226–1232.

    PubMed  Google Scholar 

  2. Bailar JC III, Gornik HL. Cancer undefeated. N Engl J Med 1997; 336: 1569–1574.

    Article  PubMed  Google Scholar 

  3. Lambert T, Guillioux A, Oshima A, et al. Incidence and mortality form stomach cancer in Japan, Slovenia and the USA. Int J Cancer 2002; 97: 811–818.

    Article  CAS  PubMed  Google Scholar 

  4. Kurumatani N, Kirita T, Zheng Y, Sugimura M, Yonemasu K. Time trends in the mortality rates for tobacco-and alcohol-related cancers within the oral cavity and pharynx in Japan, 1950–1994. J Epidemiol 1999; 9: 46–52.

    CAS  PubMed  Google Scholar 

  5. Tamakoshi K, Kondo T, Yatsuya H, Hori Y, Kikkawa F, Toyoshima H. Trends in mortality (1950–1997) and incidence (1975–1993) of malignant ovarian neoplasm among Japanese women: Analyses by age, time, and birth cohort. Gynecol Oncol 2001; 83: 64–71.

    Article  CAS  PubMed  Google Scholar 

  6. Statistics and Information Department, Minister's Secretariat, Ministry of Health and Welfare. Vital Statistics of Japan. 1950–1995. Tokyo: Yamato Sogo Printing, 1952–1997 (In Japanese).

    Google Scholar 

  7. Bureau of Statistics, Office of the Prime Minister. Bureau, Ministry of Finance. Population of Japan, 1950–2000. Tokyo: Yamato Sogo Printing, 1953–2002.

    Google Scholar 

  8. Osaka Cancer Registry. Survival of cancer patients in Osaka 1975–1989. Osaka: Osaka Foundation for Prevention of Cancer and Circulatory Diseases, 1998 (in Japanese).

    Google Scholar 

  9. Parkin DM, et al. (eds) Cancer incidence in five continents, vol. VI, Lyon: IARC Scientific Publications No. 120, International Agency for Research on Cancer, 1992.

    Google Scholar 

  10. The Osaka Prefectural Department of Public Health, Osaka Medical Association, Osaka Medical Center for Cancer and Cardiovascular Diseases. Annual Report of Osaka Cancer Registry No. 61-Cancer incidence and medical care in Osaka in 1998 and the survival in 1994. Osaka: Osaka Prefectural Department of Public Health, 2001 (in Japanese).

    Google Scholar 

  11. Hirayama T. The epidemiology of cancer of the stomach. Itocho 1968; 3: 787–795 (in Japanese).

    Google Scholar 

  12. Kawai K, Takada H, Takekoshi T, et al. Double contrast radiograph on routine examination of the stomach. Am J Gastroenterol 1970; 53: 147–153.

    CAS  PubMed  Google Scholar 

  13. Takemori K, Mikami S, Nihira S, Sasaki N. Relationship of urinary sodium and potassium and of urinary sodium/creatinine, potassium/creatinine and sodium/potassium ratios to stomach cancer and cerebrovascular disease moralities in Japanese women. Tohoku J Exp Med 1993; 171: 185–194.

    CAS  PubMed  Google Scholar 

  14. Hirohata T, Kono S. Diet/nutrition and stomach cancer in Japan. Int J Cancer 1997; Suppl 10: 34–36.

    Google Scholar 

  15. Asaka M, Sugiyama T, Nobuta A, Kato M, Takeda H, Graham DY. Atrophic gastritis and intestinal metaplasia in Japan: Results of a large multicenter study. Helicobacter 2001; 6: 294–299.

    CAS  PubMed  Google Scholar 

  16. Asaka M, Kimura T, Kudo M, et al. Relationship of Helicobacter pylori to serum pepsinogens in an asymptomatic Japanese population. Gastroenterology. 1992; 102: 760–766.

    CAS  PubMed  Google Scholar 

  17. Section of Nutrition, Bureau of Public Health, Ministry of Health and Welfare. National Nutrition Survey, 1986–1999. Tokyo: Daiichi Publishing Co., 1988–2001 (in Japanese).

    Google Scholar 

  18. Japan Tobacco Co. Ltd. Japan Tobacco's Annual Survey in 1960 to 2001, 1961–2002.

  19. Talamini R, Bosetti C, La Vecchia C, et al. Combined effect of tobacco and alcohol on laryngeal cancer risk: A case-control study. Cancer Causes Control 2002; 13: 957–964.

    Article  CAS  PubMed  Google Scholar 

  20. Bonnin-Scaon S, Lafon P, Chasseigne G, Mullet E, Sorum PC. Learning the relationship between smoking, drinking alcohol and the risk of esophageal cancer. Health Educ Res 2002; 17: 415–424.

    Article  PubMed  Google Scholar 

  21. Pitard A, Brennan P, Clavel J, et al. Cigar, pipe, and cigarette smoking and bladder cancer risk in European men. Cancer Causes Control 2001; 12: 551–556.

    Article  CAS  PubMed  Google Scholar 

  22. Ministry of Health and Welfare. Annual Report on Health and Welfare in 1995. Tokyo: Health and Welfare Statistics Association, 1997, 92 p (in Japanese).

    Google Scholar 

  23. Fuchs CS, Giovannucci EL, Colditz GA, et al. Dietary fiber and the risk of colorectal cancer and adenoma in women. N Engl J Med 1999; 340: 169–176.

    Article  CAS  PubMed  Google Scholar 

  24. Schatzkin A, Lanza E, Corle D, et al. Lack of effect of a low-fat, high-fiber diet on the recurrence of colorectal adenomas. Polyp Prevention Trial Study Group. N Engl J Med 2000; 342: 1149–1155.

    Article  CAS  PubMed  Google Scholar 

  25. Alberts DS, Martinez ME, Roe DJ, et al. Lack of effect of a high-fiber cereal supplement on the recurrence of colorectal adenomas. Phoenix Colon Cancer Prevention Physicians' Network. N Engl J Med 2000; 342: 1156–1162.

    Article  CAS  PubMed  Google Scholar 

  26. Michels KB, Giovannucci E, Joshipura KJ, et al. Prospective study of fruit and vegetable consumption and incidence of colon and rectal cancers. J Natl Cancer Inst 2000; 92: 1740–1752.

    Article  CAS  PubMed  Google Scholar 

  27. Lubin F, Ruder AM, Way Y, Modan B. Overweight and changes in weight throughout adult life in breast cancer etiology: A case-control study. Am J Epidemiol 1985; 122: 579–588.

    CAS  PubMed  Google Scholar 

  28. La Guardia M, Giammanco M. Breast cancer and obesity. Panminerva Med 2001; 43: 123–133.

    CAS  PubMed  Google Scholar 

  29. Singletary SE. Rating the risk factors for breast cancer. Ann Surg 2003; 237: 474–482.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Hygiene, Hirosaki University School of Medicine, Zaifu-cho 5, Hirosaki, 036-8562, Japan

    Shigeyuki Nakaji, Qiang Liu, Tatsuya Yamamoto, Yukika Kakuta & Kazuo Sugawara

  2. First Department of Internal Medicine, Hirosaki University School of Medicine, Zaifu-cho 5, Hirosaki, Japan

    Juichi Sakamoto

  3. Department of Health Studies, University of Chicago, 5841 S. Maryland Avenue, Chicago, IL, USA

    John C. Bailar

Authors
  1. Shigeyuki Nakaji
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  2. Qiang Liu
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  3. Tatsuya Yamamoto
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  4. Yukika Kakuta
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  5. Juichi Sakamoto
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  6. Kazuo Sugawara
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  7. John C. Bailar
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Correspondence to Shigeyuki Nakaji.

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Nakaji, S., Liu, Q., Yamamoto, T. et al. Firm measures are required to effect any significant decrease in the Japanese age-adjusted mortality rate from malignant neoplasms for the 21st century. Eur J Epidemiol 19, 123–128 (2004). https://doi.org/10.1023/B:EJEP.0000017665.58070.19

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  • DOI: https://doi.org/10.1023/B:EJEP.0000017665.58070.19

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