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Markers of fetal growth and serum levels of insulin-like growth factor (IGF) I, -II and IGF binding protein 3 in adults

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Abstract

Fetal growth has been linked with increased risk of cancer and cardiovascular disease later in life. The insulin-like growth factor (IGF) axis has recently been proposed as a predictor of risk of subsequent cancer and cardiovascular disease. However, only few data are available on the possible association between fetal growth and levels of IGFs later in life. We examined the association between markers of fetal growth, i.e. birth weight, birth length and Ponderal Index, from birth records and serum IGF-I, IGF-II, and IGF binding protein 3 (IGFBP-3) levels in 545 middle-aged Danish men and women. We fitted separate multivariate models including birth weight, birth length, Ponderal Index and serum IGF-I, IGF-II, and IGFBP-3, respectively. After adjustment for age, alcohol intake, smoking, diabetes mellitus, systolic and diastolic blood pressure, serum total cholesterol and current height and weight, we found negative associations between birth weight and Ponderal Index, respectively, and serum IGF-II in men, i.e. the mean regression coefficients were −49.41 (95% CI: −87.06–11.77) (μg/l)/kg and −3.49 (95% CI: −6.73–0.25) (μg/l)/(kg/m3), respectively. Furthermore, in men birth weight was negatively associated with the (IGF-I + IGF-II)/IGFBP-3 and IGF-II/IGFBP-3 ratios, which are believed to be indicators of bioavailable IGF and IGF-II, respectively. However, no other associations were found in any of the models. Between 1 and 16% of the variance in serum IGF-I, IGF-II, and IGFBP-3, respectively, could be explained by the statistical models used in the analyses. We found very little support to the hypothesis of an association between fetal growth and the IGF axis throughout life.

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References

  1. Forsdahl A. Are poor living conditions in childhood and adolescence an important risk factor for arteriosclerotic heart disease? Br J Prev Soc Med 1977; 31: 91-95.

    Google Scholar 

  2. Joseph KS, Kramer MS. Review of the evidence on fetal and early childhood antecedents of adult chronic disease. Epidemiol Rev 1996; 18: 158-174.

    Google Scholar 

  3. Barker DJP. Fetal origins of coronary heart disease. Br Med J 1995; 311: 171-174.

    Google Scholar 

  4. Fall CH, Osmond C, Barker DJP, et al. Fetal and infant growth and cardiovascular risk factors in women. Br Med J 1995; 310: 428-432.

    Google Scholar 

  5. Ekbom A, Hsieh CC, Lipworth L, et al. Perinatal characteristics in relation to incidence and mortality from prostate cancer. Br Med J 1996; 313: 337-341.

    Google Scholar 

  6. Ekbom A, Hsieh CC, Lipworth L, Adami HQ, Trichopoulos D. Intrauterine environment and breast cancer risk in women: A population-based study. J Natl Cancer Inst 1997; 89: 71-76.

    Google Scholar 

  7. Andersson SW, Bengtsson C, Hallberg L, et al. Cancer risk in Swedish women: The relation to size at birth. Br J Cancer 2001; 84: 1193-1198.

    Google Scholar 

  8. Ekbom A. Growing evidence that several human cancers may originate in utero. Semin Cancer Biol 1998; 8: 237-244.

    Google Scholar 

  9. Gluckman PD. The endocrine regulation of fetal growth in late gestation: The role of insulin-like growth factors. J Clin Endocrinol Metab 1995; 80: 1047-1050.

    Google Scholar 

  10. Gluckman PD, Pinal CS. Maternal-placental-fetal interactions in the endocrine regulation of fetal growth. Endocrine 2002; 19: 81-89.

    Google Scholar 

  11. Chan JM, Stampfer MJ, Giovannucci E, et al. Plasma insulin-like growth factor-I and prostate cancer risk: A prospective study. Science 1998; 279: 563-566.

    Google Scholar 

  12. Hankinson SE, Willett WC, Colditz GA, et al. Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet 1998; 351: 1393-1396.

    Google Scholar 

  13. Ruotolo G, Båvenholm P, Brismar K, et al. Serum insulin-like growth factor-I level is independently associated with coronary artery disease progression in young male survivors of myocardial infarction: Beneficial effects of bezafibrate treatment. J Am Coll Cardiol 2000; 35: 647-654.

    Google Scholar 

  14. Frystyk J, Ledet T, Møller N, Flyvbjerg A, Ørskov H. Cardiovascular disease and insulin-like growth factor I. Circulation 2002; 106: 893-895.

    Google Scholar 

  15. Juul A, Scheike T, Davidsen M, Gyllenborg J, Jørgensen T. Low serum insulin-like growth factor I is associated with increased risk of ischemic heart disease. Circulation 2002; 106: 939-944.

    Google Scholar 

  16. Fall CHD, Pandit AN, Law CM, et al. Size at birth and plasma insulin-like growth factor-1 concentrations. Arch Dis Child 1995; 73: 287-293.

    Google Scholar 

  17. Garnett S, Cowell CT, Bradford D, et al. Effects of gender, body composition and birth size on IGF-I in 7-and 8-year old children. Horm Res 1999; 52: 221-229.

    Google Scholar 

  18. Jernström H, Olsson H. Insulin-like growth factor-1 in relation to adult weight and birth weight in healthy nulliparous women. Int J Gynaecol Obstet 1998; 62: 11-18.

    Google Scholar 

  19. Lauritzen T, Lebouef-Yde C, Lunde IM, Nielsen KDB. Ebeltoft project: Baseline data from a five year randomized, controlled, prospective health promotion study in a Danish population. Br J Gen Prac 1995; 45: 542-547.

    Google Scholar 

  20. Frystyk J, Dinesen B, Ørskov H. Non-competitive time-resolved immunofluorometric assays for determination of human insulin-like growth factor I and II. Growth Regul 1995; 5: 169-176.

    Google Scholar 

  21. Greenland S. Modeling and variables selection in epidemiologic analysis. Am J Public Health 1989; 79: 340-349.

    Google Scholar 

  22. Juul A, Dalgaard P, Blum WF, et al. Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children and adolescents: The relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation. J Clin Endocrinol Metab 1995; 80: 2534-2542.

    Google Scholar 

  23. Frystyk J, Skjaerbaek C, Dinesen B, Ørskov H. Free insulin-like growth factors (IGF-I and IGF-II) in human serum. FEBS Lett 1994; 384: 185-191.

    Google Scholar 

  24. Collett-Solberg PF, Cohen P. Genetics, chemistry, and function of the IGF/IGFBP system. Endocrine 2000; 12: 121-136.

    Google Scholar 

  25. D'Ercole AJ, Ye P, Gutierrez-Ospina G. Use of transgenic mice for understanding the physiology of insulin-like growth factors. Horm Res 1996; 45(Suppl 1): 5-7.

    Google Scholar 

  26. Yang SW, Yu JS. Relationship of insulin-like growth factor-I, insulin-like growth factor binding protein-3, insulin, growth hormone in cord blood and maternal factors with birth height and birthweight. Pediatr Int 2000; 42: 31-36.

    Google Scholar 

  27. Woods KA, Camacho-Hübner C, Savage MO, Clark AJL. Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulinlike growth factor I gene. N Engl J Med 1996; 335: 1363-1367.

    Google Scholar 

  28. Vaessen N, Janssen JA, Heutink P, et al. Association between genetic variation in the gene for insulin-like growth factor-I and low birthweight. Lancet 2002; 359: 1036-1037.

    Google Scholar 

  29. Gluckman PD, Harding JE. Fetal growth retardation: Underlying endocrine mechanisms and postnatal consequences. Acta Paediatr Suppl 1997; 422: 69-72.

    Google Scholar 

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Authors and Affiliations

  1. Department of Clinical Epidemiology, Aarhus University Hospital and Aalborg Hospital, Aarhus, Denmark

    S.P. Johnsen & H.T. Sørensen

  2. Aarhus, Denmark

    S.P. Johnsen

  3. Department of General Practice and Research Unit, University of Aarhus, Aarhus, Denmark

    J.L. Thomsen, M. Engberg & T. Lauritzen

  4. Medical Department M (Diabetes and Endocrinology), Aarhus University Hospital, Aarhus, Denmark

    H. Grønbæk & A. Flyvbjerg

  5. Medical Department V (Hepatology and Gastroenterology), Aarhus University Hospital, Aarhus, Denmark

    H. Grønbæk

Authors
  1. S.P. Johnsen
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  2. H.T. Sørensen
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  3. J.L. Thomsen
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  4. H. Grønbæk
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  5. A. Flyvbjerg
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  6. M. Engberg
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  7. T. Lauritzen
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Johnsen, S., Sørensen, H., Thomsen, J. et al. Markers of fetal growth and serum levels of insulin-like growth factor (IGF) I, -II and IGF binding protein 3 in adults. Eur J Epidemiol 19, 41–47 (2004). https://doi.org/10.1023/B:EJEP.0000013396.40006.8f

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  • DOI: https://doi.org/10.1023/B:EJEP.0000013396.40006.8f

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