Skip to main content
SpringerLink
Log in

CASE REPORT: Toxic Hepatitis After Sequential Administration of Flutamide and Cyproterone Acetate

  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Ridell JG, Harron DW, Shanks RG: Clinical pharmacokinetics of beta-adrenoreceptor antagonists. An update. Clin Pharmacokinet 12(5):305-320, 1987

    Google Scholar 

  2. Borchard U: Pharmacokinetics of beta-adrenoreceptor blocking agents: Clinical significance of hepatic and/or renal clearance. Clin Phys Biochem 8 (Suppl)2:28-34, 1990

    Google Scholar 

  3. Crawford ED, Eisenberger MA, McLeod DG, et al.: A conrolled trial of leuprorelide with and without flutamide in prostatic carcinoma. N Engl J Med 321:419-424, 1989

    Google Scholar 

  4. Friedman A, Narcross MJ, Rein M: Adverse effects of leuprorelide acetate depot treatment. Fertil Steril 59:448-450, 1993

    Google Scholar 

  5. Migliari R, Muscas G, Murru M, et al.: Antiandrogens: A summary review of pharmacodynamic properties and tolerability in prostate cancer therapy. Arch Ital Urol Androl 71(5):293-302, 1999

    Google Scholar 

  6. Gomez JL, Dupont A, Cusan L, et al.: Incidence of liver toxicity associated with the use of flutamide in prostate cancer patients. Isr J Med 92:465-470, 1992

    Google Scholar 

  7. Wysowski D, Freiman JP, Tourtelot JP, et al.: Fatal and nonfatal hepatotoxicity associated with flutamide. Ann Intern Med 118:860-864,1992

    Google Scholar 

  8. Garcia Cortes M, Andrade RJ, Lucena MI, et al.: Flutamide-induced hepatotoxicity: report of a case series. Rev Esp Enferm Dig 93(7):419-422, 2001

    Google Scholar 

  9. Dourakis S, Alexopoulou A, Hadziyannis S: Fulminant hepatitis after flutamide treatment. J Hepatol 20:350-353, 1994

    Google Scholar 

  10. Cetin M, Demirci D, Unal A, et al.: Frequency of flutamide induced hepatotoxicity in patients with prostate carcinoma. Hum Exp Toxicol 18(3):137-140, 1999

    Google Scholar 

  11. Hinkel A, Berges RR, Pannek J, et al.: Cyproterone acetate in the treatment of advanced prostatic cancer: retrospective analysis of liver toxicity in the long–term follow up of 89 patients. Eur Urol 30(4):464-470, 1996

    Google Scholar 

  12. Levesque H, Trivalle C, Manchon ND, et al.: Fulminant hepatitis due to cyproterone acetate. Lancet I:215-216, 1989

    Google Scholar 

  13. Parys BT, Hamid S, Thomson RGN: Severe hepatocellular dysfunction following cyproterone acetate therapy. Br J Urol 67:312-313, 1991

    Google Scholar 

  14. Hirsch D, Kovatz S, Bernheim J, et al.: Fatal fulminant hepatitis from cyproterone acetate. Isr J Med Sci 30:238-242, 1994

    Google Scholar 

  15. Bressolette L, Dubois A, Carlhant D, et al.: Fatal hepatitis caused by cyproterone acetate. Therapie 49(2):153, 1994

    Google Scholar 

  16. Friedman G, Lamoureux E, Sherker A: Fatal fulminant hepatic failure due to cyproterone acetate. Dig Dis Sci 44(7):1362-1363, 1999

    Google Scholar 

  17. Scheuer PJ: Liver biopsy interpetation, 4th ed. Philadelphia, Bailliere Tindall, 1988, pp 99-112

    Google Scholar 

  18. Trauner M, Graziadei IW: Review article: mechanisms of action and therapeutic applications of ursodeoxycholic acid in chronic liver diseases. Aliment Pharmacol Ther 13(8):979-996, 1999

    Google Scholar 

  19. Kallinowski B, Theilmann L, Zimmermann R, et al.: Effective treatment of cyclosporine–induced cholestasis in heart–transplanted patients treated with ursodeoxycholic acid. Transplantation 51:1128-1129, 1991

    Google Scholar 

  20. Cicognani C, Malavolti M, Morselli–Labate A, et al.: Flutamide–induced toxic hepatitis. Potential utility of ursodeoxycholic acid administration in toxic hepatitis. Dig Dis Sci 41(11):2219-2221, 1996

    Google Scholar 

  21. Soza A, Riquelme F, Alvarez M, et al.: Hepatotoxicity by amoxycillin/clavulanic acid: case report. Rev Esp Enferm Dig 90(7):523-526, 1998

    Google Scholar 

  22. Barrio J, Castiella A, Lobo C, et al.: Cholestatic acute hepatitis induced by amoxycillin–clavulanic acid combination. Role of ursodeoxycholic acid in drug–induced cholestasis. Rev Esp Enferm Dig 90(7):523-526, 1998

    Google Scholar 

  23. Katsinelos P, Vasiliadis T, Xiarchos P, et al.: Ursodeoxycholic acid (UDCA) for the treatment of amoxycillin–clavulanate potassium (Augmentin)–induced intra–hepatic cholestasis: Report of two cases. Eur J Gastroenterol Hepatol 12(3):365-368, 2000

    Google Scholar 

  24. Habscheid W, Abele U, Dahm HH: Severe cholestasis with kidney failure from anabolic steroids in a body builder. Dtsch Med Wochenschr 124(36):1029-1032, 1999

    Google Scholar 

  25. Salmon L, Montet JC, Oddoze C, et al.: Ursodeoxycholic acid and prevention of tacrine–induced hepatotoxicity: a pilot study. Therapie 56(1):29-34, 2001

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Gastroenterology, Polyclinic General Hospital, Athens, Greece

    Spilios Manolakopoulos, Sotirios Bethanis, Anastasios Armonis, Michalis Economou & Dimitrios Tzourmakliotis

  2. Second Department of Gastroenterology, Evangelismos General Hospital, Athens, Greece

    Alec Avgerinos

Authors
  1. Spilios Manolakopoulos
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sotirios Bethanis
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Anastasios Armonis
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Michalis Economou
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Alec Avgerinos
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Dimitrios Tzourmakliotis
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Manolakopoulos, S., Bethanis, S., Armonis, A. et al. CASE REPORT: Toxic Hepatitis After Sequential Administration of Flutamide and Cyproterone Acetate. Dig Dis Sci 49, 462–465 (2004). https://doi.org/10.1023/B:DDAS.0000020504.41500.9c

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/B:DDAS.0000020504.41500.9c

Search

Navigation