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Nizatidine and Cisapride Increase Salivary Secretion in Rats

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Abstract

Saliva is a neurally induced solution with buffering capacity against acidic solutions. Salivation therefore plays an important role in defending the esophageal mucosa against refluxed gastric acid and is evoked by cholinergic stimulation. Both nizatidine and cisapride are reported to increase acetylcholine concentrations in the postganglionic cholinergic synapses. We performed this study to clarify the effect of administration of nizatidine and cisapride on salivary secretion. Eight-week-old male Sprague–Dawley rats were used for the experiments. Histamine-stimulated gastric acid secretion was measured after intraduodenal administration of nizatidine or famotidine to determine the equipotent acid-suppressing doses. Salivary secretion was then measured for 3 hr after intraduodenal administration of nizatidine (30 mg/kg), famotidine (3 mg/kg), or cisapride (1 mg/kg). Both nizatidine and famotidine dose-dependently inhibited histamine-stimulated gastric acid secretion. Total salivary secretion was significantly increased by nizatidine (P = 0.02) and cisapride (P = 0.02) but not by famotidine (P = 0.50) compared with controls.

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Authors and Affiliations

  1. Department of Gastroenterology and Hepatology, Shimane University, Shimane, Japan

    Kyoichi Adachi, Kenji Furuta, Tomoko Katsube, Tomoo Fujisawa, Takane Azumi, Hirofumi Fujishiro, Shunji Ishihara & Yoshikazu Kinoshita

  2. Department of Gastrointestinal Endoscopy, Shimane University, Shimane, Japan

    Yuji Amano

Authors
  1. Kyoichi Adachi
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  2. Kenji Furuta
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  3. Tomoko Katsube
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  4. Tomoo Fujisawa
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  5. Takane Azumi
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  6. Hirofumi Fujishiro
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  7. Shunji Ishihara
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  8. Yuji Amano
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  9. Yoshikazu Kinoshita
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Adachi, K., Furuta, K., Katsube, T. et al. Nizatidine and Cisapride Increase Salivary Secretion in Rats. Dig Dis Sci 49, 399–403 (2004). https://doi.org/10.1023/B:DDAS.0000020492.16088.28

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  • DOI: https://doi.org/10.1023/B:DDAS.0000020492.16088.28

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