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Prognostic Significance and Correlation with Survival of bcl-2 and TGF-β RII in Colon Cancer

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Abstract

Bcl-2 and TGF-β receptors type II (RII) in colon carcinomas were studied in a series of 113 patients, to determine their prognostic significance and to correlate their expression with other prognostic indicators. Bcl-2 expression in the tumor cells showed a reverse relation with tumor size (P=0.018), histological grade (P=0.04), and stage (P=0.013). Univariate survival analysis using the log rank test showed that the survival of patients with bcl-2-positive tumors was significantly better than the survival of patients with bcl-2-negative tumors (P=0.02). However, when entered into a multivariate analysis model, it was not found to be of independent prognostic significance. TGF-β RII expression was correlated with stage (P=0.03), while no statistically significant correlation was found between TGF-β RII expression and histological grade or survival. In conclusion, these results provide additional evidence for the role of bcl-2 and TGF-β RII in carcinogenesis of the colon, while they do not support the use of these factors as prognostic markers in patients with colon cancer.

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Authors and Affiliations

  1. The Second Department of Propedeutic Surgery, Athens University School of Medicine, Laiko Hospital, Athens, Greece

    Gregory Kouraklis, John Kakisis, Stamatios Theoharis, Antonia Tzonou, Andromachi Glinavou, John Raftopoulos & Gabriel Karatzas

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  1. Gregory Kouraklis
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  2. John Kakisis
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  3. Stamatios Theoharis
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Correspondence to Gregory Kouraklis.

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Kouraklis, G., Kakisis, J., Theoharis, S. et al. Prognostic Significance and Correlation with Survival of bcl-2 and TGF-β RII in Colon Cancer. Dig Dis Sci 48, 2284–2289 (2003). https://doi.org/10.1023/B:DDAS.0000007864.24866.77

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  • DOI: https://doi.org/10.1023/B:DDAS.0000007864.24866.77

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