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Antioxidant Activity of Phenolic Metabolites from Marine Sponges

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Chemistry of Natural Compounds Aims and scope

Abstract

The marine-sponge metabolitesilimaquinone (1), isospongiaquinone(2),puupenone(3), 15-methoxypuupenol (4), 2-methyl-2-pentaprenyl-6-hydroxychromene (5), (+)-curcuphenol (6), (+)-curcudiol (7), and semisynthetic sesquiterpenequinones (8-11) were investigated for ability to trap the free radical 1,1,-diphenyl-2-picrylhydrazyl (DPPH), to inhibit Fe2+ /ascorbate-induced oxidation of lipidsfromrat-brain homogenate, and to inhibit oxidation of linseed oil. It was shown that metabolites 3-5 were the most active antioxidants.

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Authors and Affiliations

  1. Pacific Institute of Bioorganic Chemistry, Far-East Division, Russian Academy of Sciences, 690022, Vladivostok, pr. Stoletiya Vladivostoka, 159

    N. K. Utkina

  2. Institute of Chemistryand Applied Ecology, Division of Bioorganic Chemistryand Biotechnology, Far-East State University, 690600, Vladivostok, ul. Oktyabr'skaya, 27

    A. E. Makarchenko, O. V. Shchelokova & M. V. Virovaya

Authors
  1. N. K. Utkina
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  2. A. E. Makarchenko
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  3. O. V. Shchelokova
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  4. M. V. Virovaya
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Utkina, N.K., Makarchenko, A.E., Shchelokova, O.V. et al. Antioxidant Activity of Phenolic Metabolites from Marine Sponges. Chemistry of Natural Compounds 40, 373–377 (2004). https://doi.org/10.1023/B:CONC.0000048251.58246.22

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  • DOI: https://doi.org/10.1023/B:CONC.0000048251.58246.22

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