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Studies on Pyrazine Derivatives. 38. Synthesis, Reactions, and Tuberculostatic Activity of Pyrazinyl-substituted Derivatives of Hydrazinocarbodithioic Acid

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The synthesis of N'-[amino(6-chloro- and 6-cycloaminopyrazin-2-yl)methylene]carbodithioic acid mono- and diesters and their reactions are described. Cyclization of monoesters with secondary amines in acidic media gave the 1,3,4-thiadiazole derivatives, while the cyclization of diesters with amines yielded 1,2,4-triazoles with the amine substituent in position 3. The in vitro tuberculostatic activity of the prepared compounds was tested.

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Authors and Affiliations

  1. Department of Organic Chemistry, Medical University of Gdansk, 80-416, Gdansk, Poland

    H. Foks & I. Trapkowska

  2. Department of Microbiology, Institute of Tuberculosis and Pulmonary Diseases 01-138 Warszawa, Poland

    M. Janowiec, Z. Zwolska & E. Augustynowicz-Kopec

Authors
  1. H. Foks
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  2. I. Trapkowska
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  3. M. Janowiec
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  4. Z. Zwolska
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  5. E. Augustynowicz-Kopec
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Foks, H., Trapkowska, I., Janowiec, M. et al. Studies on Pyrazine Derivatives. 38. Synthesis, Reactions, and Tuberculostatic Activity of Pyrazinyl-substituted Derivatives of Hydrazinocarbodithioic Acid. Chemistry of Heterocyclic Compounds 40, 1185–1193 (2004). https://doi.org/10.1023/B:COHC.0000048293.68655.d5

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  • DOI: https://doi.org/10.1023/B:COHC.0000048293.68655.d5

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