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Synthesis, Structure, and Some Properties of Substituted 3-Carbethoxy(methoxy)-5-cyano-1,2,3,4-tetrahydrospirocyclohexane-4-pyridine-2-thiones

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Abstract

The condensation of cyclohexylidenemalononitrile or cyclohexylidenecyanoacetic ester with thioamidoethyl(methyl)malonate in the presence of sodium ethylate gave 6-amino-3-carbethoxy-5-cyano-4-spirocyclohexane-1,2,3,4-tetrahydropyridine-2-thione and 3-carbethoxy(methoxy)-5-cyano-6-oxo-4-spirocyclohexanepiperidine-2-thiones which were used in the synthesis of the corresponding substituted 2-alkylthiotetrahydropyridines. 5-Carbethoxy-3-cyano-3-methyl-6-methylthio-4-spiro-cyclohexane-3,4-dihydropyridine-2(1H)-one was studied by X-ray crystallography.

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Authors and Affiliations

  1. Taras Shevchenko National Pedagogical University, Lugansk, 91011, Ukraine

    A. D. Dyachenko & V. D. Dyachenko

  2. V. N. Karazin National University, Kharkov, 61070, Ukraine

    S. M. Desenko

  3. Organic Chemistry Institute, Ukraine National Academy of Sciences, Kiev, 02094

    A. N. Chernega

Authors
  1. A. D. Dyachenko
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  2. S. M. Desenko
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  3. V. D. Dyachenko
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  4. A. N. Chernega
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Dyachenko, A.D., Desenko, S.M., Dyachenko, V.D. et al. Synthesis, Structure, and Some Properties of Substituted 3-Carbethoxy(methoxy)-5-cyano-1,2,3,4-tetrahydrospirocyclohexane-4-pyridine-2-thiones. Chemistry of Heterocyclic Compounds 40, 1009–1016 (2004). https://doi.org/10.1023/B:COHC.0000046690.75207.9b

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  • DOI: https://doi.org/10.1023/B:COHC.0000046690.75207.9b

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