Abstract
We have used the reaction of 4-aminodiphenyl ester with acrylic, methacrylic, crotonic, and itaconic acids to synthesize N-substituted β-alanines, which undergo ring closure to form derivatives of dihydropyrimidinedione and 4-carboxy-2-pyrrolidinone. We have studied the reactions of acylation and recyclization of the dihydropyrimidinedione ring, and we have synthesized derivatives of 4-carboxy-1-(4-phenoxyphenyl)-2-pyrrolidinone: arylidene hydrazides, 2[(2-oxo-4-pyrrolidinyl-1-(4-phenoxyphenyl)]benzimidazole.
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Mickevicius, V., Mickevicius, M. & Vaickelioniene, R. Synthesis and Cyclization of N-(4-Phenoxyphenyl)-β-alanines. Chemistry of Heterocyclic Compounds 40, 781–787 (2004). https://doi.org/10.1023/B:COHC.0000040775.12740.81
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DOI: https://doi.org/10.1023/B:COHC.0000040775.12740.81