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Synthesis of Quinoline-8-selenol, Its Complex Compounds with Metals and Their Cytotoxic Activity

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

We have developed a novel method for synthesis of quinoline-8-selenol using selenourea instead of the previously used potassium selenocyanate. We have synthesized a series of metal quinoline-8-selenolates. We have studied the cytotoxic activity of the synthesized compounds against HT-1080, MG-22A, B16, Neuro 2A tumor cells. Mercury quinoline-8-selenolate is distinguished by high cytotoxicity for the three cell lines; the cadmium complex is most effective against B16 melanoma cells.

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Authors and Affiliations

  1. Institute of Inorganic Chemistry, Riga Technical University, Salaspils, LV-2169, Latvia

    J. Ashaks, Yu. Bankovsky, D. Zaruma, I. Domracheva, A. Nesterova & E. Lukevics

  2. Latvian Institute of Organic Synthesis, Riga, LV-1006, Latvia

    I. Shestakova

Authors
  1. J. Ashaks
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  2. Yu. Bankovsky
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  3. D. Zaruma
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  4. I. Shestakova
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  5. I. Domracheva
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  6. A. Nesterova
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  7. E. Lukevics
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Ashaks, J., Bankovsky, Y., Zaruma, D. et al. Synthesis of Quinoline-8-selenol, Its Complex Compounds with Metals and Their Cytotoxic Activity. Chemistry of Heterocyclic Compounds 40, 776–780 (2004). https://doi.org/10.1023/B:COHC.0000040774.96325.d1

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  • DOI: https://doi.org/10.1023/B:COHC.0000040774.96325.d1

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