Abstract
Reactions of the dipeptides (Gly2, Ala2) themselves and in combination with amino acids (AA) (glycine, alanine, valine, leucine, proline) and glycine oligopeptides (Gly3, Gly4, Gly5) on activated alumina surface were investigated. Reactions of glycine oligopeptides led to the formation of longer-chain oligomers up to Gly11. Combinations of Gly2 with other amino acids led to various reactions proceeding by different reaction mechanisms. In the reactions of Gly2 with AA, cyclic anhydride (cyc(Gly2)) formation was followed by AA addition and molecular rearrangement leading to the formation of Gly-Gly-AA tripeptides. In the reaction of Ala2 with glycine, this type of reaction apparently does not proceed readily, although very high yields of cyc(Ala2) are formed. The reactivities of the individual components are not always reflected in reactions of their mixtures.
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Bujdák, J., Rode, B. Peptide Bond Formation on the Surface of Activated Alumina: Peptide Chain Elongation. Catalysis Letters 91, 149–154 (2003). https://doi.org/10.1023/B:CATL.0000007148.33571.f7
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DOI: https://doi.org/10.1023/B:CATL.0000007148.33571.f7