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Evaluation of overall fibrinolytic activity in patients with coronary artery ectasia: Global fibrinolytic capacity

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Abstract

Objective: Since the role of fibrinolytic activity is unclear in coronary artery ectasia, we investigated the entire fibrinolytic activity by a new test, global fibrinolytic capacity (GFC) in the ectasia patients. Methods and results: Thirty-four ectasia patients (18 male, mean age: 58 ± 8 years) presenting with acute coronary syndrome and 25 controls (14 male, mean age: 56 ± 9 years) with normal coronary artery were evaluated. GFC, D-dimer and other hemostatic factors were assessed. Clinical characteristics were comparable in both groups. Serum GFC (4.6 ± 2.1 vs. 3.1 ± 2.1 μg/ml, p = 0.03) and D-dimer levels (0.69 ± 0.42 vs. 0.41 ± 0.38 ng/ml, p = 0.02, respectively) were significantly higher in ectasia patients than in controls. They were also higher in subgroup of patients with myocardial infarction (four patients) compared with other ectasia patients and controls (p = 0.04, 0.01, respectively). Other hemostatic factors were not different in both groups. GFC was correlated with D-dimer (r = 0.76, p = 0.01). Conclusion: Our results suggest that fibrinolytic system activation may develop in ectasia patients with acute coronary syndrome. It can be induced by thrombus formation in ectatic segment of coronary artery.

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Authors and Affiliations

  1. Department of Cardiology, Suleyman Demirel University, Medical School, Isparta, Turkey

    Abdullah Dogan, Oktay Ergene, Mehmet Ozaydin, Cem Nazli, Ahmet Altinbas & Omer Gedikli

  2. Department of Pediatric Hematology, Suleyman Demirel University, Medical School, Isparta, Turkey

    Bahattin Tunc

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  1. Abdullah Dogan
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  2. Bahattin Tunc
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  3. Oktay Ergene
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  4. Mehmet Ozaydin
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  5. Cem Nazli
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  6. Ahmet Altinbas
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  7. Omer Gedikli
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Dogan, A., Tunc, B., Ergene, O. et al. Evaluation of overall fibrinolytic activity in patients with coronary artery ectasia: Global fibrinolytic capacity. Int J Cardiovasc Imaging 19, 465–471 (2003). https://doi.org/10.1023/B:CAIM.0000004339.30038.8d

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  • DOI: https://doi.org/10.1023/B:CAIM.0000004339.30038.8d

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