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Insulin-like growth factor binding protein-3: relationship to the development of gastric pre-malignancy and gastric adenocarcinoma (United Kingdom)

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Abstract

IGF family proteins play a pivotal role in regulating cell growth and apoptosis in normal and tumour tissues. IGFBP-3 is the major binding protein of IGFs and modulates the bioactivity of IGFs. To examine the role of IGFBP-3 in gastric cancer, an IGFBP3 promoter polymorphism, and serum and gastric mucosal levels of IGFBP-3 were assessed in two independent groups of patients (396 and 117 patients, respectively) with gastroduodenal diseases. There was no significant association between IGFBP-3 polymorphism and different gastroduodenal diseases (p = 0.6), but a significantly higher frequency of CC, a genotype related to lower levels of serum IGFBP-3 previously, were observed in patients with antral intestinal metaplasia when compared with those without this pre-malignancy (p = 0.04). Similarly, data from another independent group of patients further showed that patients with antral or corpus intestinal metaplasia had significantly lower serum levels of IGFBP-3 than those without these changes (p = 0.03 and 0.04, respectively). Furthermore, the percentage of positive IGFBP-3 staining in tumour tissue was significantly higher in patients with well or moderately differentiated tumours than those with poorly differentiated tumours (p = 0.04), indicating that IGFBP-3 may be associated with a better prognosis. In conclusion, our study suggests that IGFBP-3 may be protective against the development of gastric adenocarcinoma by preventing the formation of intestinal metaplasia and improve the prognosis of gastric cancer.

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Authors and Affiliations

  1. Division of Surgery, Bristol Royal Infirmary, University of Bristol, Bristol, BS2 8HW, UK

    Zun-Wu Zhang, Paul V. Newcomb, Paul Savage, Andrew Hollowood, Derek Alderson & Jeff M.P. Holly

  2. Department of Histopathology, Bristol Royal Infirmary, University of Bristol, Bristol, BS2 8HW, UK

    Moganaden Moorghen & Jyoti Gupta

  3. Department of Histopathology, St Bartholomew's and the Royal London School of Medicine and Dentistry, Turner Street, London, E1, UK

    Roger Feakins

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  1. Zun-Wu Zhang
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  2. Paul V. Newcomb
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  3. Moganaden Moorghen
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  4. Jyoti Gupta
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  6. Paul Savage
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  7. Andrew Hollowood
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  9. Jeff M.P. Holly
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Correspondence to Zun-Wu Zhang.

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Zhang, ZW., Newcomb, P.V., Moorghen, M. et al. Insulin-like growth factor binding protein-3: relationship to the development of gastric pre-malignancy and gastric adenocarcinoma (United Kingdom). Cancer Causes Control 15, 211–218 (2004). https://doi.org/10.1023/B:CACO.0000019510.96285.e9

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  • DOI: https://doi.org/10.1023/B:CACO.0000019510.96285.e9

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