Abstract
Summary: Malonylcarnitine and glutarylcarnitine are important diagnostic metabolites in the screening of dried blood spots by tandem mass spectrometry. The stability of these compounds in spiked blood spots stored at room temperature was studied. Both showed biphasic curves. The malonylcarnitine concentration dropped to 61% in 38 days and averaged 51%±5% for the next 81 days. Glutarylcarnitine dropped to 60% in 42 days and averaged 56%±5% for the next 124 days.
This is a preview of subscription content, log in via an institution to check access.
REFERENCES
Baric I, Zschocke J, Christensen E,et al (1998)Diagnosis and management of glutaric aciduria type I.J Inherit Metab Dis 21:326-340.
Johnson DW(2004)Synthesis of dicarboxylic acylcarnitines.Chem Phys Lipids 129:161-171.
Santer R, Fingerhut R, Lassker U,et al (2003)Tandem mass spectrometric determination of malonylcarnitine:diagnosis and neonatal screening of malonyl-CoA decarboxylase deficiency.Clin Chem 49:660-662.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Johnson, D.W., Trinh> , MU. Stability of malonylcarnitine and glutarylcarnitine in stored blood spots. J Inherit Metab Dis 27, 789–790 (2004). https://doi.org/10.1023/B:BOLI.0000045830.82698.90
Issue Date:
DOI: https://doi.org/10.1023/B:BOLI.0000045830.82698.90