Biochemistry (Moscow)

, Volume 69, Issue 10, pp 1055–1066 | Cite as

Apoptosis in Unicellular Organisms: Mechanisms and Evolution

  • A. V. Gordeeva
  • Y. A. Labas
  • R. A. Zvyagilskaya
Article

Abstract

Data about the programmed death (apoptosis) in unicellular organisms, from bacteria to ciliates, are discussed. Firstly apoptosis appeared in lower eukaryotes, but its mechanisms in these organisms are different from the classical apoptosis. During evolution, the apoptotic process has been improving gradually, with reactive oxygen species and Ca2+ playing an essential role in triggering apoptosis. All eukaryotic organisms have apoptosis inhibitors, which might be introduced by viruses. In the course of evolution, caspases and apoptosis-inducing factor appeared before other apoptotic proteins, with socalled death receptors being the last among them. The functional analogs of eukaryotic apoptotic proteins take parts in the programmed death of bacteria.

apoptosis bacteria Ca2+ caspases death receptors evolution eukaryotes reactive oxygen species 

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Copyright information

© MAIK “Nauka/Interperiodica” 2004

Authors and Affiliations

  • A. V. Gordeeva
    • 1
  • Y. A. Labas
    • 1
  • R. A. Zvyagilskaya
    • 1
  1. 1.Bach Institute of BiochemistryRussian Academy of SciencesMoscowRussia

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