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Isolation and Identification of a New Thymic Peptide from Calf Thymus

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Abstract

Various thymic peptides (including thymulin, thymic humoral factor, thymopoietin, etc.) play important roles in the process of T cell maturation and development. We isolated a new peptide from calf thymus and named it thymus activity factor II (TAF-II). A yield of 0.92 mg of TAF-II was purified from 500 g calf thymus. Analysis by LC/MSD-Trap showed the amino acid sequence of this hexapeptide to be Glu-Ala-Lys-Ser-Gln-Gly-OH with molecular weight 618.5 daltons. We have also begun to investigate the influence of TAF-II.

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Authors and Affiliations

  1. State Key Laboratory of Biomembranes and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, 100084, China

    Xi-Ming Qin, Ming-Xing Duan, Bin Deng, Xi-Cheng Liu, Qiang-Zhe Zhang, Zheng Liu & Hong-Xuan He

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  1. Xi-Ming Qin
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  2. Ming-Xing Duan
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  3. Bin Deng
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  4. Xi-Cheng Liu
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  5. Qiang-Zhe Zhang
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  6. Zheng Liu
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  7. Hong-Xuan He
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Correspondence to Ming-Xing Duan.

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Qin, XM., Duan, MX., Deng, B. et al. Isolation and Identification of a New Thymic Peptide from Calf Thymus. Biochemistry (Moscow) 69, 921–925 (2004). https://doi.org/10.1023/B:BIRY.0000040226.21454.d3

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  • DOI: https://doi.org/10.1023/B:BIRY.0000040226.21454.d3

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