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Regulation of Gene Expression via Triple Helical Formations

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Abstract

Triplex-forming oligonucleotides (TFOs) are a challenging and very promising subject in modern biochemistry and molecular genetics. Over the last decade, several studies have stated that TFOs: a) can bind to DNA in a sequence-specific manner; b) can provoke DNA repair and recombination in mammalian cells, and c) can be a very effective biological tool in embryonic and oncogenic research on gene expression pathways. Herein we review the basic modes in which TFOs exist, their gene-regulation properties, as well as the obstacles that should be overcome before they become useful in clinical practice (chemotherapy and/or gene therapy).

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Authors and Affiliations

  1. Department of Experimental Pharmacology, Medical School, University of Athens, 75 Mikras Asias str., 11527, Athens, Greece

    V. Karympalis, K. Kalopita, A. Zarros & H. Carageorgiou

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  1. V. Karympalis
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  2. K. Kalopita
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  3. A. Zarros
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  4. H. Carageorgiou
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Karympalis, V., Kalopita, K., Zarros, A. et al. Regulation of Gene Expression via Triple Helical Formations. Biochemistry (Moscow) 69, 855–860 (2004). https://doi.org/10.1023/B:BIRY.0000040216.18119.d5

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  • DOI: https://doi.org/10.1023/B:BIRY.0000040216.18119.d5

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