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Interaction of Polymer Aggregates Based on Stearoyl-poly-N-vinylpyrrolidone with Blood Components

Abstract

Stearoyl-poly-N-vinylpyrrolidone (PVP-stear) of various molecular weights (Mn = 1500-5500) self-assemble in aqueous medium. Particles prepared from PVP-stear were characterized in terms of shape and size distribution, and the mechanical stability of the particles was studied. The interaction of PVP-stear and its aggregates with blood components was investigated. Aggregates formed by the polymers with Mn = 1500-3500 in the presence of human serum are stable. The direct lytic action of PVP-stear preparations was studied using sheep and human erythrocytes. The influence of PVP-stear aggregates on the activation of complement system both on classical and alternative pathways was examined. The aggregates prepared from PVP-stear of various molecular weights had no effect on the activation of the complement system.

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Correspondence to N. I. Larionova.

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Villemson, A.L., Kuskov, A.N., Shtilman, M.I. et al. Interaction of Polymer Aggregates Based on Stearoyl-poly-N-vinylpyrrolidone with Blood Components. Biochemistry (Moscow) 69, 621–628 (2004). https://doi.org/10.1023/B:BIRY.0000033735.34356.21

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  • self-assembling systems
  • amphiphilic polymer
  • stearoyl-poly-N-vinylpyrrolidone
  • colloidal particles
  • blood serum
  • erythrocytes
  • complement system