Abstract
Natural heparin complexes proved to activate the anticoagulation system. The obtained experimental data convincingly confirm that glutamic acid alone, and particularly in a complex with heparin, has a considerable preventive potential and efficiently protects experimental animals with induced diabetes mellitus.
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REFERENCES
Astrup, T. and Müllertz, S., The Fibrin Plate Method for Estimating Fibrinolytic Activity, Arch. Biochem. Byophys., 1952, vol. 40, pp. 346-351.
Balabolkin, M.I., Morozova, T.N., and Chagiashvili, M.V., A New Method for Treatment of Disturbed Homeostasis in Type I Diabetes Patients, Aktual'nye problemy gemostaza v klinicheskoi praktike. Tez. dokl. Vsesoyuz. Konf. (Actual Problems of Hemostasis in Clinical Practice), 1987, Moscow, pp. 9-10.
Barrowcliffe, T.W., Studies of Heparin to Antitrombin III by Crossed Immunoelectrophoresis, Thrombosis. Haemostas., 1980, vol. 42, no. 5, pp. 1434-1445.
Born, G.V.R., Aggregation of Blood Platelet by Adenosin-diphosphate, Nature, 1962, vol. 194, pp. 927-929.
Dolgov, V.V., Avdeeva, N.A., and Shchetnikovich, K.A., Metody issledovaniya gemostaza (Methods for Studying Hemostasis), Moscow: Meditsina, 1996, pp. 1-59.
Kantorovich, L.S., USSR Inventor's Certificate no. 158399, Byull. Izobret., 1963, no. 21.
Kudrjashov, B.A. and Lyapina, L.A., Non-Enzymatic Fibrinolysis and Its Role in the Organism, Thrombosis and Thrombolysis, Chasov, E.I. and Smirnov, V.N., Eds., New York: Consultants Bureau, 1986, pp. 33-65.
Lyapina, L.A. and Pastorova, V.E., Activation of the Anticoagulation System by Complexes of Heparin and Amino Acids, Trombozy, DVS-sindrom. Problemy lecheniya. V Vserosiiskaya konferentsiya (Thromboses and DIC Syndrome. Problems of Treatment. V All-Russian Conf.), 2000, pp. 114-115.
Lyapina, L.A. and Ziadetdinova, G.A., Complex Compound of Heparin and Glutamic Acid: Synthesis and Effect on Hemostatic Indices in vitro and in vivo, Izv. Akad. Nauk. Ser. Biol., 2001, no. 1, pp. 82-86.
Lyapina, L.A., Pastorova, V.E., Kamenskii, A.A., Myasoedov, N.F., and Ashmarin, I.P., Heparin-Semax Complex and Its Effect on Anticoagulant and Fibrinolytic Properties of Animal Plasma, Vopr. Biol. Med. Farm. Khim., 2000, no. 3, pp. 33-36.
McKay, E.J. and Laurell, G.B., The Interaction of Heparin with Plasma Proteins. Demonstration of Different Binding Sites for Antithrombin III Complexes and Antithrombin III, J. Lab. Clin. Med, 1980, vol. 95, no. 1, pp. 69-80.
Smolina, T.Yu., Pastorova, V.E., and Lyapina, L.A., Complex Formation of Pro-Gly Dipeptide and Heparin: A Study of the Complex Hemostatic Properties in vitro and after Intravenous Administration, Tromboz, Gemostaz, Reologiya, 2002, no. 2, pp. 38-41.
Ul'yanov, A.M., Functional State of the Insular and Anticoagulation Systems in Animals during Stable Alloxan Diabetes, Vestn. Moscow State University. Ser. 16. Biol., 1994, no. 4, pp. 32-37.
Valverde, I., Vicent, D., Villanueva-Penacarrillo, M.L., and Malaisse-Lagae, F., Stimulation of Insulin Release in vivo by the Methyl Esters of Succinic Acid and Glutamic Acid, Adv. Exp. Med. Biol., 1997, vol. 426, pp. 231-234.
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Ul'yanov, A.M., Lyapina, L.A., Pastorova, V.E. et al. Antidiabetic and Anticoagulant Properties of Heparin–Glutamic Acid Complex. Biology Bulletin 31, 281–284 (2004). https://doi.org/10.1023/B:BIBU.0000030150.02722.9f
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DOI: https://doi.org/10.1023/B:BIBU.0000030150.02722.9f