Abstract
Antibacterial preparation dioxidine administered four times in doses of 10, 100, and 300 mg/kg increased the incidence of micronucleated cells in the bone marrow, lungs, and large intestine of mice. Bone marrow cells were most sensitive, while cells of the lungs and large intestine exhibited lower sensitivity to the cytogenetic effect of dioxidine.
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REFERENCES
S. K. Abilev and M. M. Abdrazakov, Genetika, 27, No. 11, 2039–2041 (1991).
Manual on Antibacterial Therapy, Eds. L. S. Strachunskii et al. [in Russian], Moscow (2000).
T. S. Bakai and L. M. Fronshtein, Mol. Genet., No. 4, 35–39 (1987).
S. N. Kuzovatov, V. Yu. Kravtsov, and Yu. B. Vakhtin, Tsitologiya, 42, No. 11, 1097–1102 (2000).
Study of Mutagenic Activity of Chemical Substances by the Micronuclear Method: Methodical Recommendations [in Russian], Moscow (1984).
E. A. Rudzit, A. M. Bespalov, and R. F. Tagirov, Farmakol. Toksikol., No. 4, 472–473 (1974).
S. B. Seredinin and A. D. Durnev, Pharmacological Protection of Genome [in Russian], Moscow (1992).
L. P. Sycheva, Byull. Eksp. Biol. Med., 131, No. 4, 445–447 (2001).
M. V. Usol'tsev, A. D. Durnev, and S. B. Seredinin, Eksper. Klin. Farmakol., 63, No. 2, 60–62 (2000).
L. M. Fonshtein, Yu. A. Revazova, G. N. Zolotareva, et al., Genetika, 15, No. 6, 901–908 (1978).
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Sycheva, L.P., Kovalenko, M.A., Sheremeteva, S.M. et al. Study of Mutagenic Activity of Dioxidine by the Polyorgan Micronuclear Method. Bulletin of Experimental Biology and Medicine 138, 165–167 (2004). https://doi.org/10.1023/B:BEBM.0000048377.39895.99
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DOI: https://doi.org/10.1023/B:BEBM.0000048377.39895.99