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Comparative Analysis of Accumulation of Chlorine e6 and Hematoporphyrin Derivatives in Subpopulations of Peripheral Blood Lymphocytes

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Abstract

We studied accumulation of porphyrin photosensitizers chlorine e6, hematoporphyrin, and their derivatives by different lymphocyte subpopulations. The intensity of staining of B lymphocytes and natural killer cells with photosensitizers was higher compared to T lymphocytes. T cell subpopulation differed by their ability to bind photosensitizers. Relative accumulation of dimethyl esters of chlorine e6 and hematoporphyrin in cells surpassed that of nonesterified porphyrins.

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Authors and Affiliations

  1. Republican Research-and-Production Center for Child Oncology and Hematology, Minsk

    V. P. Savitskii, V. P. Zorin, M. P. Potapnev & A. Ya. Potapenko

  2. Belarussian State University, Minsk

    V. P. Savitskii, V. P. Zorin, M. P. Potapnev & A. Ya. Potapenko

  3. Russian State Medical University, Moscow

    V. P. Savitskii, V. P. Zorin, M. P. Potapnev & A. Ya. Potapenko

Authors
  1. V. P. Savitskii
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  2. V. P. Zorin
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  3. M. P. Potapnev
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  4. A. Ya. Potapenko
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Savitskii, V.P., Zorin, V.P., Potapnev, M.P. et al. Comparative Analysis of Accumulation of Chlorine e6 and Hematoporphyrin Derivatives in Subpopulations of Peripheral Blood Lymphocytes. Bulletin of Experimental Biology and Medicine 138, 158–162 (2004). https://doi.org/10.1023/B:BEBM.0000048375.50335.7b

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  • DOI: https://doi.org/10.1023/B:BEBM.0000048375.50335.7b

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